穴位敷贴联合腹腔灌注治疗老年中晚期肝癌患者腹水的效果观察  

Observation of acupoint application and peritoneal perfusion in treating malignant ascites in the elderly with middle and advanced liver cancer

作　　者：吴蕾 徐森华 潘春梅 WU Lei;XU Senhua;PAN Chunmei(Department of Hematology and Oncology,Pudong Hospital Affiliated to Fudan University,Shanghai 201300)

机构地区：[1]复旦大学附属浦东医院肿瘤血液内科,上海浦东201300

出　　处：《河北中医》2024年第8期1358-1362,共5页Hebei Journal of Traditional Chinese Medicine

基　　金：上海市浦东新区区科委基金项目(编号:PKJ2019-Y34)。

摘　　要：目的研究自拟散水方穴位敷贴外敷联合腹腔灌注榄香烯注射液治疗老年中晚期肝癌患者腹水的临床疗效。方法选取2019年1月至2022年12月我院住院老年中晚期肝癌伴腹水140例患者为此次试验的对象,随机将其分成2组,各70例。对照组采用常规腹腔灌注榄香烯注射液治疗,治疗组在对照组的基础上加用自拟散水方外敷穴位,每3周为1个疗程,连续使用2个疗程。比较2组治疗前后中医症候积分、腹水改善情况、肝功能及凝血指标,比较2组治疗过程中不良反应发生情况。结果腹水改善总有效率治疗组高于对照组(治疗组为81.5%,对照组为61.4%,P<0.05),2组治疗后腹部胀满、腹部青筋、神疲乏力、胸闷、纳差食少、面色晦暗分较治疗前降低,且治疗组降低幅度优于对照组(P<0.05);治疗组甲胎蛋白、凝血功能、肝功能均较对照组明显改善,差异有统计学意义(P<0.05)。结论腹腔灌注榄香烯结合穴位敷贴在老年中晚期肝癌腹水患者治疗中的疗效确切,可较好的改善患者的临床相关症状,改善肝功能和凝血功能,提高治疗疗效,且不增加药物不良反应,值得临床应用推广。Objective To explore the clinical effect of acupoint application with self-planned Sanshui Formula combined with peritoneal perfusion treatment of elemene injection in treating ascites in the elderly with middle and advanced liver cancer.Methods A total of 140 middle and advanced liver cancer elderly patients with liver ascites from January 2019 to December 2022 were enrolled as study subjects.The patients were randomly assigned to the control group(n=70)or the treatment group(n=70).All patients were given conventional peritoneal perfusion treatment(elemene injection),and those in the treatment group were additionally given acupoint application with self-planned Sanshui Formula.A two-course of treatment was performed(every 3 weeks for 1 course),aiming to compare traditional Chinese medicine(TCM)syndrome score,ascites level,liver function,coagulation index,and adverse reactions between groups before and after treatment.Results The total effective rate in treatment group was significantly higher than that in control group(81.5%vs 61.4%,P<0.05).After treatment,the TCM symptom scores(abdominal distension,abdominal bruises,fatigue,chest tightness,poor appetite,and dark complexion)in the both groups were significantly lower than those before treatment,and the decrease in the treatment group was more pronounced relative to the control group(P<0.05).The alpha-fetoprotein(AFP),coagulation function,and liver function in the treatment group were significantly improved compared with the control group(P<0.05).Conclusion For middle and advanced liver cancer elderly patients with liver ascites,peritoneal perfusion treatment of elemene injection combined with acupoint application has a definite therapeutic effect,which can effectively improve clinical symptoms,liver function and coagulation function,improve treatment efficacy,and does not increase adverse drug reactions.It is worthy of clinical application and promotion.

关 键 词：原发性肝癌 腹水 穴位敷贴 

分 类 号：R244.9[医药卫生—针灸推拿学]