1416例疱疹性咽峡炎患儿流行病学及血常规特点分析  

Analysis of epidemiological and blood routine characteristics of 1416 children with herpetic angina

作　　者：梁茜[1] 卢秀 谭丽琴 梁琼 唐娟[1] 张若杰 LIANG Qian;LU Xiu;TAN Liqin;LIANG Qiong;TANG Juan;ZHANG Ruojie(Department of Hospital Infection Management,the Second Affiliated Hospital of Guangxi Medical University,Guangxi,Nanning 530007,China;Department of Pediatrics,the Second Affiliated Hospital of Guangxi Medical University,Guangxi,Nanning 530007,China)

机构地区：[1]广西医科大学第二附属医院医院感染管理科,广西南宁530007 [2]广西医科大学第二附属医院儿科,广西南宁530007

出　　处：《中国医药科学》2024年第14期63-66,共4页China Medicine And Pharmacy

基　　金：广西壮族自治区中医药管理局自筹经费科研课题(GXZYA20220250)。

摘　　要：目的分析研究疱疹性咽峡炎患儿临床特征及发病时血常规特点,为疱疹性咽峡炎诊断和治疗提供临床参考。方法选取广西医科大学第二附属医院急诊儿科2022年6月至2023年5月收治的1416例疱疹性咽峡炎患儿为研究对象,所有患儿均收集基本病例资料并采集血样检测白细胞计数(WBC)、中性粒细胞百分比(NEU%)、超敏C反应蛋白(hs-CRP)水平,从病例中抽取100例WBC>15×10^(9)/L的患儿,根据病历记载是否使用抗生素分为观察组和对照组,并比较观察组和对照组患儿临床疗效和WBC恢复情况。结果1416例疱疹性咽峡炎主要发生在1~6岁儿童中,占全部收治患儿的87.43%,临床症状以发热、咳嗽、胃纳欠佳为主,惊厥、呕吐及肢体抖动症状较为少见;发病高峰期集中在5~6月份,尤其是6月份,其发病率最高达51.27%;WBC、NEU%、hs-CRP平均值分别(11.52±1.02)×10^(9)/L、(71.78±4.95)%、(10.36±1.04)mg/L。根据年龄分为<1岁、1~3岁、4~6岁、>6岁组,四组患儿WBC、NEU%、hs-CRP水平比较,差异有统计学意义(P<0.05);WBC>15×10^(9)/L的患儿治疗5 d后,两组患儿的WBC均降低,但两组比较差异无统计学意义(P>0.05)。结论疱疹性咽峡炎重点人群为1~6岁儿童,高峰期为春末夏初季节,应在高峰期做好重点人群的防控措施,减少发病率。临床多见发热、咳嗽、胃纳欠佳等症状。血常规特点主要表现为WBC、NEU%、hs-CRP水平轻度升高,不能仅以WBC升高作为疱疹性咽峡炎使用抗菌药物的依据。Objective To analyze the clinical features and blood routine characteristics of children with herpetic angina,so as to provide clinical reference for the diagnosis and treatment of herpetic angina.Methods The subjects were 1416 children with herpetic angina treated in the Pediatric Emergency Department of the Second Affiliated Hospital of Guangxi Medical University from June 2022 to May 2023.The basic case data of all children were acquired and blood samples were collected to detect the levels of white blood cell count(WBC),neutrophil percentage(NEU%)and high-sensitivity C-reactive protein(hs-CRP).100 children with WBC>15×10^(9)/L were selected from the cases and divided into the observation group and the control group according to whether antibiotics were used or not.The clinical efficacy and WBC recovery of children in the observation group and the control group were compared.Results 1416 cases of herpetic angina mainly occurred in children aged 1-6 years,accounting for 87.43%of all the children admitted.The main clinical symptoms were fever,cough and poor appetite,while convulsion,vomiting and limb trembling were rare.The peak period of onset was from May to June,especially in June,with the highest incidence rate of 51.27%.The average WBC,NEU%and hs-CRP were(11.52±1.02)×10^(9)/L,(71.78±4.95)%and(10.36±1.04)mg/L,respectively.These children were divided into<1 year old,1-3 years old,4-6 years old and>6 years groups old according to their age.The levels of WBC,NEU%and hs-CRP in the four groups were statistically different.After 5 d of treatment,the children with WBC>15×10^(9)/L decreased in both groups,but there was no statistical difference between the two groups(P>0.05).Conclusion The key population of herpetic angina is children aged 1-6 years,and the peak time is late spring and early summer.Therefore,prevention and control measures should be taken to reduce the incidence of herpetic angina.Symptoms such as fever,cough and poor appetite are common in clinic.The blood routine is characterized by a slight

关 键 词：疱疹性咽峡炎 流行病学特征 血常规特点 防控要点 

分 类 号：R766.12[医药卫生—耳鼻咽喉科]