机构地区:[1]广东省东莞市松山湖中心医院儿科,广东东莞523320 [2]广东省东莞市松山湖中心医院新生儿科,广东东莞523320
出 处:《中国医药科学》2024年第14期70-73,共4页China Medicine And Pharmacy
基 金:广东省东莞市社会发展科技面上项目(20211800900832)。
摘 要:目的分析中枢神经特异性蛋白(S100-β)表达在早产儿脑损伤中的应用价值。方法选取2021年10月至2023年1月在东莞市松山湖中心医院接受治疗的34例脑损伤早产儿作为病例组,选取同一时期在本院出生的46例新生儿作为对照组,比较分析两组的S100-β表达异常情况、早产儿相关指标、预后相关指标以及不同时间点S100-β表达水平。结果病例组早产儿的S100-β表达异常率高于对照组,差异有统计学意义(P<0.05),新生儿行为神经测定(NBNA)评分、运动表现测试(TIMP)评分(纠正40周)、TIMP评分(纠正4个月)均低于对照组,差异有统计学意义(P<0.05),且病例组早产儿的S100-β表达水平随时间延长而降低,且不同时间点S100-β表达水平比较,差异有统计学意义(P<0.05)。而在预后良好组和预后不良组早产儿的相关指标比较中,预后良好组早产儿的S100-β水平低于预后不良组,且TIMP评分(纠正40周)、TIMP评分(纠正4个月)均高于预后不良组,差异有统计学意义(P<0.05)。结论S100-β指标检测应用于早产儿脑损伤的诊断中,能够充分反映早产儿脑损伤病情和预后情况,可提示医疗工作者及时给予脑损伤早产儿康复治疗,改善其生存质量,具有较高的临床应用价值。Objective To analyze the application value of central nervous system specific proteins(S100-β)expression in premature infants with brain injury.Methods Premature infants with brain injury admitted to and treated in the Songshan Lake Central Hospital of Dongguan City from October 2021 to January 2023 were selected as the observation objects of the case group(n=34),and neonates born in our hospital in the same period were selected as the observation objects of the control group(n=46).The abnormal expression of S100-β,premature infants-related indices,prognosis-related indices and S100-βexpression levels at different time points between the two groups were compared and analyzed.Results The abnormal rate of S100-βexpression in premature infants of the case group was higher than that of the control group,with statistically significant difference(P<0.05).The scores of neonatal behavioral neurological assessment(NBNA),test of infant motor performance(TIMP)(corrected for 40 weeks)and TIMP(corrected for 4 months)were all lower than those in the control group,with statistically significant differences(P<0.05).Meanwhile,the expression levels of S100-βin premature infants of the case group decreased with time,and the expression levels of S100-βat different time points were compared,with statistically significant differences(P<0.05).In the comparison of related indices of premature infants between the group of good prognosis and the group of poor prognosis,the S100-βlevel of premature infants in the group of good prognosis was lower than that of the group of poor prognosis,and the TIMP score(corrected for 40 weeks)and TIMP score(corrected for 4 months)were all higher than those in the group of poor prognosis,with statistically significant differences(P<0.05).Conclusion S100-βindex detection applied to the diagnosis in premature infants with brain injury can fully reflect the condition and prognosis of them,and can prompt medical workers to give rehabilitation treatment to premature infants with brain injury in time to
关 键 词:早产儿 脑损伤 S100-β 新生儿行为神经测定评分 运动表现测试评分
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