内镜下不同比例聚桂醇泡沫硬化剂注射联合套扎术治疗Ⅱ~Ⅲ度内痔的临床效果  

Clinical effect on the treatment of degreeⅡandⅢinternal hemorrhoids by injection of different proportions of lauromacrogol foam sclerosant combined with ligation under endoscope

作　　者：王家旭 覃屹 谢榕[1] 罗期 唐少波[1] 张伟伟[1] WANG Jiaxu;QIN Yi;XIE Rong;LUO Qi;TANG Shaobo;ZHANG Weiwei(Department of Gastroenterology,the First People’s Hospital of Nanning,Guangxi,Nanning 535000,China)

机构地区：[1]南宁市第一人民医院消化内科,广西南宁535000

出　　处：《中国医药科学》2024年第14期147-150,190,共5页China Medicine And Pharmacy

基　　金：广西壮族自治区南宁市科学研究与技术开发计划项目(20223049-2)。

摘　　要：目的探讨不同比例的聚桂醇泡沫硬化剂注射联合套扎术治疗Ⅱ~Ⅲ度内痔的有效性及安全性。方法选取2019年12月至2022年12月南宁市第一人民医院消化内科收治的90例内痔患者,按随机数表法将患者分为A、B、C三组。A组为聚桂醇原液组;B组为1∶1聚桂醇泡沫硬化剂组;C组为1∶2聚桂醇泡沫硬化剂组,每组各30例。对各组患者行硬化剂注射和套扎治疗。记录各组手术时间、聚桂醇用量、住院天数、术后疼痛、出血、疗效及异位栓塞、尿潴留、肛门感染等并发症情况。结果三组手术时间、住院天数、并发症发生率比较,差异无统计学意义(P>0.05);三组手术费用、聚桂醇用量、术后疼痛、出血以及疗效比较,差异有统计学意义(P<0.05),其中B组和C组较A组手术费用和聚桂醇用量明显减少,术后疼痛和出血发生更低,疗效明显升高。但B组和C组手术费用、聚桂醇用量、术后疼痛和出血比较,差异无统计学意义(P>0.05)。B组较C组临床疗效明显增高,差异有统计学意义(P<0.05)。结论内镜下1∶1的聚桂醇泡沫硬化注射治疗内痔具有效率高、用量少、费用低、术后出血少、疼痛轻以及并发症发生率低等特点,值得推广。Objective To explore the efficacy and safety of different proportions of lauromacrogol foam sclerosant combined with ligation in the treatment of degreeⅡandⅢinternal hemorrhoids.Methods A total of 90 patients with internal hemorrhoids admitted to the Department of Gastroenterology of the First People’s Hospital of Nanning from December 2019 to December 2022 were selected and randomly divided into three groups:A,B and C.Group A was the lauromacrogol stock solution group,group B was the 1∶1 lauromacrogol foam sclerosant group,group C was the 1∶2 lauromacrogol foam sclerosant group,with 30 patients in each group.Patients in each group were treated with sclerosant injection and ligation.The operation time,dosage of lauromacrogol,length of stay,postoperative pain and bleeding,efficacy and complications such as ectopic embolism,urinary retention and anal infection were recorded in each group.Results There was no significant difference in operation time,length of stay,incidence of complications among the three groups(P>0.05).There were statistically significant differences in operation cost,dosage of lauromacrogol,postoperative pain and bleeding,and efficacy among the three groups(P<0.05).The operation cost and dosage of lauromacrogol of group B and C were significantly lower than those of group A,the postoperative pain and bleeding were lower,and the efficacy was significantly higher.However,there was no significant difference between group B and group C in operation cost,dosage of lauromacrogol,and postoperative pain and bleeding(P>0.05).The clinical efficacy of group B was significantly higher than that of group C,with statistically significant difference(P<0.05).Conclusion The injection of 1∶1 lauromacrogol foam sclerosant under endoscope for the treatment of internal hemorrhoids has the characteristics of high efficiency,low dosage,low cost,less postoperative bleeding,light pain and low incidence of complications,which is worth popularizing.

关 键 词：内痔 聚桂醇泡沫硬化剂 消化内镜 套扎 

分 类 号：R657.18[医药卫生—外科学]