复方甘草酸苷联合西咪替丁治疗儿童过敏性紫癜的效果  

The Therapeutic Effect of Combining Cimetidine with Compound Glycyrrhizic Acid Glycoside on Pediatric Allergic Purpura

作　　者：王海燕 王建南 李霞 WANG Haiyan;WANG Jiannan;LI Xia(Department of Pediatrics,People's hospital of Shanghe county,Ji'nan 251600,China;Department of Hospital Infection Management,People's hospital of Shanghe county,Ji'nan 251600 China)

机构地区：[1]商河县人民医院儿科,济南251600 [2]商河县人民医院感染管理科,济南251600

出　　处：《中国医药指南》2024年第23期82-84,共3页Guide of China Medicine

摘　　要：目的探讨过敏性紫癜患儿采用复方甘草酸苷与西咪替丁协同治疗取得的效果。方法选取2021年10月至2023年9月期间本院收治的过敏性紫癜患儿94例,按照随机数字表予以分组。两组患儿均接受常规对症治疗,对照组47例患儿采用西咪替丁治疗,在此基础上观察组47例患儿联用复方甘草酸苷。针对两组患儿的疗效、免疫球蛋白指标、炎症因子指标、不良反应以及治疗后随访6个月的复发情况进行比较。结果总有效率评价显示,观察组结果较对照组更高(P<0.05)。观察组患儿的关节疼痛、腹痛、皮肤紫癜症状消退时间较对照组更短(P<0.05)。治疗后,观察组免疫球蛋白A(IgA)、免疫球蛋白G(IgG)、免疫球蛋白M(IgM)、白细胞介素(IL)-6、C反应蛋白(CRP)指标水平以及随访6个月的复发率均较对照组更低(P<0.05)。不良反应(ADR)评价显示,两组结果差异无统计学意义(P>0.05)。结论复方甘草酸苷联合西咪替丁治疗儿童过敏性紫癜,能够促进患儿的症状消退,改善免疫球蛋白指标,抑制炎症反应,降低病情复发。Objective Exploring the therapeutic effect of combining cimetidine with compound glycyrrhizinacid glycoside on pediatric allergic purpura.Methods A total of 94 cases of Anaphylactoid purpura admitted to this study from October 2021 to September 2023 were selected and grouped according to a random number table.Both groups of children received routine symptomatic treatment,while the control group of 47 children received cimetidine treatment.On this basis,the study group of 47 children received a combination of compound glycyrrhizin acid glycoside.Comparison of efficacy,immunoglobulin indexes,inflammatory factor indexes,adverse effects,and relapse at 6 months after treatment in the two groups.Results Evaluation of the total effective rate showed that the results were higher in the observation group than in the control group(P<0.05).Joint pain,abdominal pain,and skin purpura symptoms of children in the observation group subsided in a shorter time than those in the control group(P<0.05).After treatment,the IgM,IgG,IgA,IL-6,CRP index levels and the recurrence rate at 6-month follow-up were lower in the observation group than in the control group(P<0.05).ADR evaluation showed that the difference between the two groups was not statistically significant(P>0.05).Conclusions Compound glycyrrhizin combined with cimetidine in the treatment of children with anaphylactoid purpura can promote the regression of symptoms,improve immunoglobulin index,inhibit inflammatory response,reduce disease recurrence.

关 键 词：过敏性紫癜 复方甘草酸苷 西咪替丁 儿童 

分 类 号：R554.6[医药卫生—血液循环系统疾病] R725.5[医药卫生—内科学]