基于下丘脑-垂体-性腺轴分析淫羊藿苷对男性不育症的调控  

Analysis of the regulation of icariin on male infertility based on hypothalamic-pituitary-gonadal axis

作　　者：徐磊 张培海[2] 徐子龙[1,2] 文泓志 马紫阳 XU Lei;ZHANG Peihai;XU Zilong;WEN Hongzhi;MA Ziyang(Master Degree Candidate of Chinese Medicine Surgery Enrolled in 2022,Chengdu University of Traditional Chinese Medicine Clinical Medical College,Chengdu 610075,Sichuan,China;TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province,Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610075,Sichuan,China)

机构地区：[1]成都中医药大学临床医学院,成都610075 [2]成都中医药大学附属医院代谢性疾病中医药调控四川省重点实验室,成都610075

出　　处：《中国性科学》2024年第8期1-4,共4页Chinese Journal of Human Sexuality

基　　金：国家中医药管理局青年岐黄学者支持项目(HRS2020069);四川省中医药管理局科学技术研究专项课题(2023MS454)。

摘　　要：近年来,不育症已成为当代男性的主要社会和健康问题之一。男性不育症病因十分复杂,目前针对男性不育症的治疗手段虽然很多,但费用相对昂贵,且疗效较差。淫羊藿作为男科常用的药物,长期以来一直在中药治疗男性不育症方面发挥着重要作用。淫羊藿苷是淫羊藿的主要化学成分,近年来,对淫羊藿苷的研究主要集中在治疗勃起功能障碍、抑制肿瘤细胞生长、控制高血压及冠心病等方面,在不育症方面的研究相对较少。因此,本文基于下丘脑-垂体-性腺轴理论,详细阐述了淫羊藿苷对睾丸前性病因、睾丸性病因及睾丸后性病因导致的不育症的调控机制,以期为临床治疗不育症提供一些思路。In recent years,infertility has become one of the major social and health problems of contemporary men.The etiology of male infertility is highly intricate.Despite the existence of numerous treatment modalities for male infertility,these treatments are relatively costly and yield suboptimal outcomes.The herb epimedium is a regular remedy in the field of andrology,playing a significant role in the treatment of male infertility with traditional Chinese medicine.The main chemical component of epimedium is known as icariin.In recent years,research on icariin has primarily focused on its potential in treating erectile dysfunction,inhibiting tumor cell growth,controlling hypertension and coronary heart disease,etc.However,there has been relatively limited research conducted on its effects on infertility.Therefore,based on the theory of hypothalamic-pituitary-gonadal axis,this paper thoroughly elucidates the mechanism of icariin on infertility through pretesticular,testicular,and post-testicular causes,aiming to offer insights for clinical management of infertility.

关 键 词：淫羊藿苷 男性不育症 雄激素 下丘脑-垂体-性腺轴 

分 类 号：R697[医药卫生—泌尿科学]