男性不育症患者血清及精浆IL-38、Ang-1水平与精液质量的相关性研究  

Study on the correlation between serum and seminal plasma interleukin-38,angiotensin-1 levels and semen quality in male infertility patients

作　　者：邹晓静[1] 郝燕燕 ZOU Xiaojing;HAO Yanyan(Department of Clinical Laboratory,Wenzhou Traditional Chinese Medicine Hospital of Zhejiang Chinese Medical University,Wenzhou 325000,Zhejiang,China)

机构地区：[1]浙江中医药大学附属温州市中医院检验科,浙江温州325000

出　　处：《中国性科学》2024年第8期19-23,共5页Chinese Journal of Human Sexuality

基　　金：2022年温州市基础性科研项目(Y20220755)。

摘　　要：目的探索男性不育症患者血清及精浆中白介素-38(IL-38)、血管紧张素-1(Ang-1)表达水平,并分析其与精液质量的相关性。方法选取2021年4月至2023年4月浙江中医药大学附属温州市中医院收治的108例男性不育症患者作为研究对象,依据精液质量分为少弱精子组(n=61)和正常精子组(n=47)。采用Pearson法分析患者血清及精浆IL-38、Ang-1水平与精液质量的相关性。结果少弱精子组患者精液质量及精浆果糖、中性α-葡糖苷酶(NAG)表达水平低于正常精子组,精浆IL-38及Ang-1表达水平高于正常精子组(P<0.05);男性不育症患者血清及精浆IL-38、Ang-1表达水平与精液质量及精浆果糖、NAG水平呈负相关。结论男性不育症少弱精子患者血清及精浆IL-38、Ang-1水平高于正常精子患者,且IL-38、Ang-1水平与精液质量相关。Objective To explore the expression levels of interleukin-38(IL-38)and angiotensin-1(Ang-1)in the serum and seminal plasma of male infertility patients and analyze their correlation with semen quality.Methods A total of 108 male infertility patients admitted to Wenzhou Traditional Chinese Medicine Hospital of Zhejiang Chinese Medical University from April 2021 to April 2023 were selected as the study subjects,and were divided into the oligoasthenozoospermia group(n=61)and the normal sperm group(n=47)based on the quality of semen.Pearson′s method was used to analyze the correlation between serum and seminal plasma IL-38 and Ang-1 levels and semen quality of the patients.Results The semen quality and the expression levels of seminal plasma fructose and semen plasma neutralα-glucosidase(NAG)in oligoasthenozoospermia group were lower than those in normal sperm group,and the expression levels of IL-38 and Ang-1 in semen of oligoasthenozoospermia group were higher than those in normal sperm group(P<0.05).Expression levels of IL-38 and Ang-1 in serum and seminal plasma of male infertility patients were negatively correlated with semen quality,seminal plasma fructose and seminal plasma NAG.Conclusions Serum and seminal plasma IL-38 and Ang-1 levels were higher in male infertility patients with oligoasthenozoospermia than in patients with normal spermatozoa,and IL-38 and Ang-1 levels correlated with semen quality.

关 键 词：男性不育症 白介素-38 血管紧张素-1 精浆 精液质量 

分 类 号：R697[医药卫生—泌尿科学]