脂代谢指标与不明原因不孕患者IVF-ET胚胎质量的相关性分析  

Correlation analysis of lipid metabolism on embryo quality in patients with unexplained infertility undergoing in vitro fertilization and embryo transfer

作　　者：王会男 冯琳 陆宏艳 许丽丽 司凡[1] WANG Huinan;FENG Lin;LU Hongyan;XU Lili;SI Fan(Department of Reproductive Medicine,Chengde Central Hospital,Chengde 067000,Hebei,China)

机构地区：[1]承德市中心医院生殖医学科,河北承德067000

出　　处：《中国性科学》2024年第8期58-61,共4页Chinese Journal of Human Sexuality

基　　金：承德市科技计划项目(202301A015)。

摘　　要：目的分析脂代谢与不明原因不孕(UI)患者体外受精-胚胎移植(IVF-ET)胚胎质量的相关性。方法选取2020年1月至2023年6月期间承德市中心医院收治的126例UI患者作为研究对象,所有患者均接受IVF-ET治疗,依据胚胎质量评估标准将患者分为优质组(n=76)与不良组(n=50)。比较两组基线资料及实验室指标,并分析IVF-ET前脂代谢指标与UI患者胚胎质量的相关性。结果不良组总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、睾酮、孕酮水平均高于优质组,高密度脂蛋白胆固醇(HDL-C)、雌二醇水平低于优质组(P<0.05);经点二列相关性验证,TC、TG、LDL-C水平与UI患者IVF-ET胚胎质量呈正相关(r>0,P<0.05),HDL-C水平与UI患者IVF-ET胚胎质量呈负相关(r<0,P<0.05)。结论脂代谢与UI患者IVF-ET胚胎质量有关,脂代谢紊乱可能会导致UI患者IVF-ET胚胎质量不良。Objective To analyze the correlation between lipid metabolism and embryo quality in patients with unexplained infertility(UI)undergoing in vitro fertilization and embryo transfer(IVF-ET).Methods A total of 126 UI patients admitted to Chengde Central Hospital from January 2020 to June 2023 were selected as the research objects.All patients received IVF-ET treatment.According to the embryo quality assessment criteria,the patients were divided into high-quality group(n=76)and poor-quality group(n=50).The baseline data and laboratory indexes of the two groups were compared,and the correlation between lipid metabolism indexes before IVF-ET and embryo quality of UI patients was analyzed.Results The levels of total cholesterol(TC),triglycerides(TG),low-density lipoprotein cholesterol(LDL-C),testosterone,and progesterone in the poor-quality group were higher than those in the high-quality group,while the levels of high-density lipoprotein cholesterol(HDL-C)and estradiol were lower than those in the high-quality group(P<0.05).Through point biserial correlation,it was confirmed that the levels of TC,TG,LDL-C were positively correlated with the quality of IVF-ET embryos in UI patients(r>0,P<0.05),while the levels of HDL-C were negatively correlated with the quality of IVF-ET embryos in UI patients(r<0,P<0.05).Conclusions Lipid metabolism is related to the quality of IVF-ET embryos in UI patients,and lipid metabolism disorders may lead to poor IVF-ET embryo quality in UI patients.

关 键 词：不明原因不孕 体外受精-胚胎移植 脂代谢 

分 类 号：R711[医药卫生—妇产科学]