Stepping up after spinal cord injury:negotiating an obstacle during walking  

作　　者：Alain Frigon Charly G.Lecomte 

机构地区：[1]Department of Pharmacology-Physiology,Faculty of Medicine and Health Sciences,Universitéde Sherbrooke,Centre de recherche du Centre Hospitalier Universitaire de Sherbrooke,Sherbrooke,QC,Canada

出　　处：《Neural Regeneration Research》2025年第7期1919-1929,共11页中国神经再生研究（英文版）

摘　　要：Every day walking consists of frequent voluntary modifications in the gait pattern to negotiate obstacles.After spinal cord injury,stepping over an obstacle becomes challenging.Stepping over an obstacle requires sensorimotor transformations in several structures of the brain,including the parietal cortex,premotor cortex,and motor cortex.Sensory information and planning are transformed into motor commands,which are sent from the motor cortex to spinal neuronal circuits to alter limb trajectory,coordinate the limbs,and maintain balance.After spinal cord injury,bidirectional communication between the brain and spinal cord is disrupted and animals,including humans,fail to voluntarily modify limb trajectory to step over an obstacle.Therefore,in this review,we discuss the neuromechanical control of stepping over an obstacle,why it fails after spinal cord injury,and how it recovers to a certain extent.

关 键 词：BIOMECHANICS locomotion NEUROPHYSIOLOGY obstacle negotiation spinal cord injury 

分 类 号：R651.2[医药卫生—外科学]