A novel flexible nerve guidance conduit promotes nerve regeneration while providing excellent mechanical properties  

作　　者：Tong Li Quhan Cheng Jingai Zhang Boxin Liu Yu Shi Haoxue Wang Lijie Huang Su Zhang Ruixin Zhang Song Wang Guangxu Lu Peifu Tang Zhongyang Liu Kai Wang 

机构地区：[1]Department of Orthopedics,the Fourth Medical Center of Chinese PLA General Hospital,Beijing,China [2]Department of Training and Sports Medicine,Characteristic Medical Center of Chinese People’s Armed Police Force,Tianjin,China [3]Medical School of Chinese PLA,Beijing,China [4]Key Laboratory of Bioactive Materials for the Ministry of Education,College of Life Sciences,Nankai University,Tianjin,China [5]Department of Orthopedics,Tianjin Hospital,Tianjin,China [6]Department of Rehabilitation Medicine,Er Quan Hospital of PAP,Wuxi,Jiangsu Province,China

出　　处：《Neural Regeneration Research》2025年第7期2084-2094,共11页中国神经再生研究（英文版）

基　　金：supported by the National Natural Science Foundation of China,No.82202718;the Natural Science Foundation of Beijing,No.L212050;the China Postdoctoral Science Foundation,Nos.2019M664007,2021T140793(all to ZL)。

摘　　要：Autografting is the gold standard for surgical repair of nerve defects>5 mm in length;however,autografting is associated with potential complications at the nerve donor site.As an alternative,nerve guidance conduits may be used.The ideal conduit should be flexible,resistant to kinks and lumen collapse,and provide physical cues to guide nerve regeneration.We designed a novel flexible conduit using electrospinning technology to create fibers on the innermost surface of the nerve guidance conduit and employed melt spinning to align them.Subsequently,we prepared disordered electrospun fibers outside the aligned fibers and helical melt-spun fibers on the outer wall of the electrospun fiber lumen.The presence of aligned fibers on the inner surface can promote the extension of nerve cells along the fibers.The helical melt-spun fibers on the outer surface can enhance resistance to kinking and compression and provide stability.Our novel conduit promoted nerve regeneration and functional recovery in a rat sciatic nerve defect model,suggesting that it has potential for clinical use in human nerve injuries.

关 键 词：aligned fibers anti-kinking helical fibers nerve guidance conduit nerve regeneration peripheral nerve injury topological guidance 

分 类 号：R318.08[医药卫生—生物医学工程]