PI3K/AKT通路在糖尿病视网膜病变中的调控作用  

Regulatory role of PI3K/AKT pathway in diabetic retinopathy

作　　者：李宝花 亢泽峰[1] 侯昕玥 王健全 宋曼 李丹玉 刘梦雨 晏鑫 Li Baohua;Kang Zefeng;Hou Xinyue;Wang Jianquan;Song Man;Li Danyu;Liu Mengyu;Yan Xin(Eye Hospital,China Academy of Chinese Medical Sciences,Beijing 100040,China;Fuzhou Traditional Chinese Medicine Hospital,Fuzhou 350001,Fujian Province,China)

机构地区：[1]中国中医科学院眼科医院,中国北京市100040 [2]中国福建省福州市中医院中医眼科,350001

出　　处：《国际眼科杂志》2024年第9期1426-1431,共6页International Eye Science

基　　金：中医药传承与创新“百千万”人才工程(岐黄工程)岐黄学者{No.国中医药人教发[2018]284号};福建省第三批柔性引进医疗卫生高层次人才团队;北京市石景山区亢泽峰名医传承工作室项目。

摘　　要：糖尿病视网膜病变(DR)是糖尿病的主要并发症之一,以神经退行性病变和微血管病变为其主要特征。目前,DR的治疗主要关注于晚期并发症的处理,没有达到理想的临床疗效。证据表明,PI3K/AKT通路作为细胞周期过程中重要的胞内信号通路之一,参与了DR发病的全过程。文章主要从PI3K/AKT信号通路的结构组成、激活和阻止途径、传导路径、调控机制和生物学功能等方面,综述其在DR中的作用,并探讨靶向PI3K/AKT通路治疗DR的潜力。Diabetic retinopathy(DR)is one of the major complications of diabetes mellitus,characterized by neurodegeneration and microangiopathy.Currently,the treatment of DR is mainly focused on the management of late complications and has not achieved the desired clinical outcome.Evidence suggests that the PI3K/AKT pathway,as one of the important intracellular signaling pathways during the cell cycle,is involved in the whole process of DR pathogenesis.This article focuses on the structural composition,activation and blocking pathways,conduction pathways,regulatory mechanisms and biological functions of the PI3K/AKT signaling pathway to review its role in DR and to explore the potential of targeting the PI3K/AKT pathway for the treatment of DR.

关 键 词：PI3K/AKT通路 糖尿病视网膜病变 神经退行性病变 微血管病变 

分 类 号：R587.2[医药卫生—内分泌] R774.1[医药卫生—内科学]