玻璃酸二甲基硅烷醇复合物对黏膜的保护作用和刺激性研究  

Protective Effect and Irritation of Dimethyl Silanol Hyaluronate on Mucosa

作　　者：孙亚奇 孙俊梅 朱立欣 英永 陈建英 汤连升 SUN Ya-qi;SUN Jun-mei;ZHU Li-xin;YING Yong;CHEN Jian-ying;TANG Lian-sheng(New Drug Evaluation Center,Shandong Academy of Pharmaceutical Sciences,Jinan 250101,China;Shandong Provincial Engineering Research Center for Mucosal and Skin Drug Delivery,Shandong Academy of Pharmaceutical Sciences,Jinan 250101,China;Shandong Provincial Key Laboratory of Mucosal and Skin Drug Delivery Technology,Shandong Freda Pharmaceutical Group Co.,Ltd.,Jinan 250101,China)

机构地区：[1]山东省药学科学院新药评价中心,山东济南250101 [2]山东省药学科学院山东省黏膜与皮肤给药工程技术研究中心,山东济南250101 [3]山东福瑞达医药集团有限公司山东省黏膜与皮肤给药技术重点实验室,山东济南250101

出　　处：《食品与药品》2024年第4期328-332,共5页Food and Drug

摘　　要：目的 评价玻璃酸二甲基硅烷醇复合物(DSHA)对黏膜的保护作用及其安全性。方法 采用蟾蜍作为实验动物,通过光学显微镜下观察蟾蜍上颚纤毛持续摆动时间,考察DSHA对鼻腔黏膜的保护作用;采用新西兰兔和金黄地鼠为实验动物,观察DSHA对新西兰兔鼻腔及金黄地鼠口腔等黏膜有无刺激性,评价DSHA作用于黏膜的安全性。结果 DSHA对新西兰兔鼻黏膜和金黄地鼠口腔黏膜均无刺激性。相对分子质量(M_(r))(780~1680)×10^(3)的DSHA能显著减轻干燥和药物对蟾蜍上颚黏膜的损伤。结论 研究表明,DSHA对新西兰兔鼻腔和金黄地鼠口腔黏膜无刺激性,且对蟾蜍上颚黏膜有明显的保护作用,可用于黏膜保护剂的开发。Objective To evaluate the protective effect and safety of dimethyl silanol hyaluronate(DSHA) on mucosa.Methods Toads were used as experimental animals,and the protective effect of DSHA on nasal mucosa was evaluated by observing the lasting time of ciliary movement in palate mucosa of toads under a light microscope.New Zealand rabbits and golden hamsters were used as experimental animals to evaluate the safety of DSHA on mucosa by observing the irritation of DSHA on nasal mucosa of New Zealand rabbits and oral mucosa of golden hamsters.Results DSHA did not irritate the nasal mucosa of New Zealand rabbits and the oral mucosa of golden hamsters.DSHA with relative molecular mass(M_(r)) of(780-1680) ×10^(3) could significantly alleviate the damage caused by dryness and drug on the palate mucosa of toads.Conclusion DSHA has no irritation on nasal cavity of rabbits and oral mucosa of golden hamsters,and has a significant protective effect on palate mucosa of toads,thus can be used for development of mucosal protective agents.

关 键 词：玻璃酸二甲基硅烷醇复合物 刺激性 鼻黏膜 安全性 纤毛运动 

分 类 号：R965.3[医药卫生—药理学]