复方阿嗪米特联合双歧杆菌三联活菌胶囊防治老年人抗生素相关性腹泻的临床效果  

Clinical effect of compound azintamide combined with bifidobacteria triple viable capsules in the prevention and treatment of antibiotic-associated diarrhea in the elderly

作　　者：张延霞 郭宗君[2] 任丽娟 刘蕾 ZHANG Yanxia;GUO Zongjun;REN Lijuan;LIU Lei(Department of Geriatrics,Taian 88 Hospital,Taian 271000,China)

机构地区：[1]泰安八十八医院老年医学科,山东泰安271000 [2]青岛大学附属医院老年医学科

出　　处：《精准医学杂志》2024年第5期455-458,共4页Journal of Precision Medicine

摘　　要：目的探讨复方阿嗪米特联合双歧杆菌三联活菌胶囊防治老年人抗生素相关性腹泻(antibiotic associated diarrhea,AAD)的临床效果及其机制。方法回顾性分析2019年10月—2021年2月泰安八十八医院老年医学科收治的感染性疾病或合并感染性疾病并静脉滴注抗生素的老年患者62例,依据治疗方式不同分为复方阿嗪米特联合双歧杆菌三联活菌治疗组(观察组)32例和双歧杆菌三联活菌治疗组(对照组)30例,均在应用抗生素的同时加服上述药物,共治疗14 d。收集两组患者治疗期间AAD发生情况、腹泻发生时间、每天腹泻次数、腹泻持续时间并进行比较,收集患者治疗前和治疗第14天时的血红蛋白(Hb)、血浆白蛋白(Alb)和总蛋白(TP)及血清中的C反应蛋白(CRP)、白细胞介素-6(IL-6)、补体C3与C4水平,进行两组治疗前后各生化指标的比较及治疗前后各生化指标差值的比较。结果观察组治疗期间AAD发生率显著低于对照组(χ^(2)=5.77,P<0.05);观察组较对照组腹泻发生时间显著延迟、平均每天腹泻次数减少、腹泻持续时间缩短(t=8.72~16.20,P<0.05);两组患者治疗第14天时,观察组血清中CRP、IL-6、C3、C4水平治疗前后差值均显著高于对照组(t=-97.39~-29.05,P<0.05);观察组血液中Hb、血浆中Alb和TP水平治疗前后差值均显著低于对照组(t=25.96~87.98,P<0.05)。结论复方阿嗪米特联合双歧杆菌三联活菌防治老年人AAD效果显著,考虑与其改善患者营养状况、提高免疫功能、减轻炎症反应有关。Objective To investigate the clinical effect and mechanism of compound azintamide combined with bifidobacteria triple viable capsules in the prevention and treatment of antibiotic-associated diarrhea(AAD)in the elderly.Methods A retrospective analysis was performed for 62 elderly patients with or comorbid with infectious diseases who were admitted to Department of Geriatrics,Taian 88 Hospital,from October 2019 to February 2021 and received intravenous drip of antibiotics,and according to the treatment method,they were divided into observation group with 32 patients(treated with compound azintamide combined with bifidobacteria triple viable capsules)and control group with 30 patients(treated with bifidobacteria triple viable capsules alone).The drugs were used in addition to antibiotics for 14 d.The two groups were compared in terms of the incidence rate of AAD,time to the onset of diarrhea,number of times of diarrhea per day,and duration of diarrhea during treatment,as well as related biochemical parameters before treatment and on day 14 of treatment,including hemoglobin(Hb),plasma albumin(Alb),total protein(TP),and the serum levels of C-reactive protein(CRP),interleukin-6(IL-6),and complement C3 and C4.[WTHX]Results Compared with the control group,the observation group had a significantly lower incidence rate of AAD during treatment(χ^(2)=5.77,P<0.05),as well as a significantly long time to the onset of diarrhea,a significant reduction in the mean number of times of diarrhea per day,and a significantly shorter duration of diarrhea(t=8.72-16.20,P<0.05).Compared with the control group on day 14 of treatment,the observation group had significantly greater changes in the serum levels of CRP,IL-6,C3,and C4(t=-97.39--29.05,P<0.05),and the differences in the levels of blood Hb,plasma Alb,and plasma TP before and after treatment in the observation group were significantly lower than those in the control group(t=25.96-87.98,P<0.05).Conclusion Compound azintamide combined with bifidobacteria triple viable capsules has a

关 键 词：腹泻 复方阿嗪米特 抗菌药 预防和治疗 药物相关性副作用和不良反应 二裂菌属 治疗结果 老年人 

分 类 号：R442.2[医药卫生—诊断学]