自愈合壳聚糖抗菌水凝胶的制备及其性能研究  

Preparation and properties of self-healing chitosan antibacterial hydrogel

作　　者：蒋安康 周聪 李闯 卢翠芬[1] 姜涛 陈振兵[2] JIANG Ankang;ZHOU Cong;LI Chuang;LU Cuifen;JIANG Tao;CHEN Zhenbing(Hubei Provincial Engineering Center of Performance Chemicals,Hubei University,Wuhan 430062,China;Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China)

机构地区：[1]湖北省功能化学品工程技术研究中心(湖北大学),湖北武汉430062 [2]华中科技大学同济医学院附属协和医院,湖北武汉430022

出　　处：《湖北大学学报（自然科学版）》2024年第5期730-738,共9页Journal of Hubei University：Natural Science

基　　金：国家自然科学基金(51603064);大学生创新创业训练计划项目(S202210512023)资助。

摘　　要：水凝胶作为生物医药领域的新型材料,因其具有特殊的性能被人们广泛研究。研究利用丙烯酸对壳聚糖进行修饰得到可溶性N-羧乙基壳聚糖CEC-NA,与本实验室自制的POSS-PEG-CHO在水溶液中通过席夫碱反应制备力学性能好、自愈合的CS-POSS-PEG水凝胶。对CEC-NA及CS-POSS-PEG水凝胶进行结构表征,并对水凝胶内部微观形貌、自愈合性、力学性能、溶胀性能、细胞相容性以及抗菌能力等一系列性质进行研究,结果表明水凝胶具有疏松多孔结构、良好的自愈合性、力学性能、溶胀性能、细胞相容性和抗菌性,在伤口敷料的方面具有潜在的应用前景。As a new material in the field of biomedicine,hydrogel has been widely studied because of its special properties.In this paper,acrylic acid was used to modify chitosan to obtain soluble N-carboxyethyl chitosan CEC-NA,which was reacted with POSS-PEG-CHO made in our laboratory in aqueous solution by Schiff base reaction to obtain CS-POSS-PEG hydrogels with good mechanical properties and self-healing.The structural of CEC-NA and CS-POSS-PEG hydrogels were characterized,and the internal micromorphology,self-healing,mechanical properties,swelling properties,cytocompatibility and antibacterial ability of hydrogels were studied.The results show that hydrogels have loose and porous structure,good self-healing,mechanical properties,swelling properties,cytocompatibility and antibacterial properties,so it has an ideal application prospect in wound dressings.

关 键 词：POSS PEG 壳聚糖改性 自愈合 水凝胶 

分 类 号：O63[理学—高分子化学]