基于数据挖掘探讨张炳厚治疗糖尿病肾病用药规律  

Exploration on the Medication Law of Zhang Binghou in Treating Diabetic Kidney Disease Based on Data Mining

作　　者：李萌雨 商海涛 张世文 赵文景[2] 蔡朕[2] 庞欣欣[3] 尹笑丹[4] LI Mengyu;SHANG Haitao;ZHANG Shiwen;ZHAO Wenjing;CAI Zhen;PANG Xinxin;YIN Xiaodan(The Second Clinical Medical College of Henan University of Chinese Medicine,Zhengzhou 450046,China;Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University,Beijing 100010,China;Henan Province Hospital of Traditional Chinese Medicine,Zhengzhou 450002,China;School of Chinese Medicine,Henan University of Chinese Medicine,Zhengzhou 450046,China)

机构地区：[1]河南中医药大学第二临床医学院,河南郑州450046 [2]首都医科大学附属北京中医医院,北京100010 [3]河南省中医院,河南郑州450002 [4]河南中医药大学中医学院,河南郑州450046

出　　处：《中国中医药信息杂志》2024年第9期58-65,共8页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：国家中医药管理局中医药古籍文献和特色技术传承专项(GZY-KJS-2020-039);国家中医临床研究基地科研项目(2019JDZX2119、2022JDZX139);河南省自然科学基金(202300410256)。

摘　　要：目的 采用数据挖掘方法分析张炳厚教授治疗糖尿病肾病的用药经验,并筛选核心药对药组。方法 选择2014年1月-2021年12月首都医科大学附属北京中医医院门诊张炳厚教授治疗糖尿病肾病处方,采用中医传承辅助平台2.5、SPSS Modeler 18及SPSS Statistics 21软件进行关联规则、聚类分析、因子分析,总结药物用药频次、性味归经、药对组合。结果 共纳入处方161首,涉及中药188味,总频次为2 220,频次较高的中药为熟地黄、龟甲、黄芪、生地黄等,药物药性以寒、温为主,药味以甘、苦为主,归经多归肾经、肝经、脾经,共得到药对关联规则14条,药物常用组合27对,聚类分析根据谱系图提取组合10个,因子分析提取公因子14个。结论 张炳厚教授治疗糖尿病肾病以培补真阴、清利湿热为主要治法,同时注重益肾固精、育阴涵阳、活血化瘀等,体现其治疗糖尿病肾病独特的学术思想。Objective To analyze Professor Zhang Binghou’s medication experience in the treatment of diabetic kidney disease using data mining methods;To screen the core medicinal pairs and medicinal groups.Methods Prescriptions of diabetic kidney disease of Professor Zhang Binghou from the outpatient department of Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University were selected from January 2014 to December 2021.TCM Inheritance Platform System 2.5,SPSS Modeler 18 and SPSS Statistics 21 software were used for association rules,clustering analysis and factor analysis to summarize the medication frequency,properties and tastes and meridians,and medicinal pairs and combinations.Results A total of 161 prescriptions were included,involving 188 kinds of Chinese materia medica,with a total frequency of 2220 time.The kinds of Chinese materia medica with higher frequency were Rehmannize Radix et Praeparata,Testudinis Carapax et Plastrum,Astragali Radix,Rehmannine Radix,etc.The main properties were cold and warm,the main tastes were sweet and bitter,and the main meridians were kidney,liver and spleen meridians.A total of 14 drug pair association rules were obtained,with 27 commonly used drug combinations.Clustering analysis extracted 10 combinations based on the spectrum,and factor analysis extracted 14 common factors.Conclusion Professor Zhang Binghou’s treatment for diabetic kidney disease takes nourishing the true yin and clearing away damp-heat as the main treatment method,and at the same time,it pays attention to tonifying kidney,consolidating essence,nourishing yin and containing yang,promoting blood circulation and removing blood stasis,etc.,which embodies Professor Zhang Binghou’s unique academic thought of treating diabetic kidney disease.

关 键 词：中医传承辅助平台 张炳厚 糖尿病肾病 数据挖掘 用药规律 

分 类 号：R2-05[医药卫生—中医学] R259.872