中药基于缺氧微环境调控糖代谢重编程干预胃癌前病变研究进展  

Research Progress in Chinese Materia Medica Regulation of Glucose Metabolism Reprogramming Intervention in Gastric Precancerous Lesions Based on Hypoxia Microenvironment

作　　者：王晓龙 宋瑞平 豆鹏程 封壮壮 孙小伟 雷东旭 杨静[1] 南青山 舒劲[2] WANG Xiaolong;SONG Ruiping;DOU Pengcheng;FENG Zhuangzhuang;SUN Xiaowei;LEI Dongxu;YANG Jing;NAN Qingshan;SHU Jin(Gansu University of Chinese Medicine,Lanzhou 730000,China;Gansu Provincial Hospital of TCM,Lanzhou 730050,China)

机构地区：[1]甘肃中医药大学,甘肃兰州730000 [2]甘肃省中医院,甘肃兰州730050

出　　处：《中国中医药信息杂志》2024年第9期179-184,共6页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：国家自然科学基金(82060860);甘肃省自然科学基金(21JR7RA588)。

摘　　要：胃癌前病变是胃癌发生和发展的关键阶段,糖代谢重编程是胃癌前病变的显著特征。缺氧微环境、低氧诱导因子是糖代谢重编程发生的重要影响因素。本文基于缺氧微环境与胃癌前病变糖代谢重编程之间的关系,归纳中药有效成分及复方改善缺氧微环境,进而调控糖酵解治疗该病的相关研究,总结得出其机制可能是抑制血管生成、调控信号通路及糖酵解关键蛋白、多个酶类表达、减少乳酸分泌、抑制细胞恶性增殖和侵袭。探讨中药改善缺氧微环境进而调控糖酵解的作用机制,为防治胃癌前病变提供参考。Precancerous lesions of gastric cancer is a key stage in the development of gastric cancer.The reprogramming of glucose metabolism is a prominent feature of precancerous lesions of gastric cancer.Hypoxic microenvironment and hypoxia-inducible factors are important factors influencing the occurrence of glucose metabolic reprogramming.This article summarized the relationship between hypoxic microenvironment and the reprogramming of glucose metabolism in precancerous lesions of gastric cancer,and concluded the relevant research on TCM compounds and effective components to improve hypoxic microenvironment and further regulate glycolysis for the treatment of this disease.It was concluded that the mechanism may be the inhibition of angiogenesis,regulation of signaling pathways and key proteins of glycolysis,expression of multiple enzymes,reduction of lactate secretion,inhibition of cell malignant proliferation and invasion.It explored the mechanism of Chinese materia medica in improving hypoxic microenvironment and regulating glycolysis,so as to provide reference for the prevention and treatment of precancerous lesions of gastric cancer.

关 键 词：胃癌前病变 缺氧微环境 糖代谢重编程 糖酵解 中药 

分 类 号：R273.52[医药卫生—中西医结合] R285[医药卫生—中医肿瘤科]