阻塞性睡眠呼吸暂停与心力衰竭相关性研究进展  

Progress in research on obstructive sleep apnea and heart failure

作　　者：李天骄 刘霖 赵力博[4] 张佐 聂庭玉[1,2] 杨玲 韩继明[1] Li Tianjiao;Liu Lin;Zhao Libo;Zhang Zuo;Nie Tingyu;Yang Ling;Han Jiming(Medical College,Yan′an University,Yan′an 716000,Shaanxi Province,China;Department of Respiratory and Critical Care Medicine,Second Medical Center,Chinese PLA General Hospital,Beijing 100853,China;National Clinical Research Center for Geriatric Diseases,Chinese PLA General Hospital,Beijing 100853,China;Graduate School,Chinese PLA General Hospital,Beijing 100853,China;Department of Stomatology,People′s Hospital of Ningxia Hui Autonomous Region,Yinchuan 750002,China)

机构地区：[1]延安大学医学院,陕西延安716000 [2]中国人民解放军总医院第二医学中心呼吸与危重症医学科,北京100853 [3]中国人民解放军总医院国家老年疾病临床医学研究中心,北京100853 [4]中国人民解放军总医院研究生院,北京100853 [5]宁夏回族自治区人民医院口腔科,银川750002

出　　处：《中华老年多器官疾病杂志》2024年第8期633-636,共4页Chinese Journal of Multiple Organ Diseases in the Elderly

基　　金：军队保健专项科研课题(22BJZ52,23BJZ27);军队装备建设应用研究项目(LB20211A010013);军队实验动物专项研究项目(SYDW_KY[2021]04)。

摘　　要：随着老龄化的进程加快,阻塞性睡眠呼吸暂停(OSA)与心力衰竭(HF)的患病率呈明显升高趋势。研究表明,OSA与HF互为因果,相互影响。OSA是HF的独立危险因素,HF又会引起OSA,这会使HF的症状进展、住院和死亡等不良后果的风险增加。OSA与HF之间的相互作用与上气道阻塞和慢性间歇性低氧密不可分。对于OSA相关性HF,目前没有明晰的诊疗方案。针对两者的发病机制及症状,HF治疗药物通常推荐与OSA的一线治疗方法持续气道正压通气合并使用。本文对OSA与HF相关性研究的最新进展予以综述,旨在为后续更有效的针对性治疗提供必要的参考。With the acceleration of ageing process,the prevalence of obstructive sleep apnea(OSA)and heart failure(HF)has been significantly increasing.Studies show that OSA and HF are causal and mutually influential.OSA is an independent risk factor for HF,which in turn causes OSA,increasing the risk of adverse outcomes such as symptom progression,hospitalization,and death in HF.The interaction between OSA and HF is inextricably linked to upper airway obstruction and chronic intermittent hypoxia.Currently,there is no definitive diagnosis and treatment protocol for OSA-associated heart failure.Considering the pathogenesis and symptoms of both,HF treatment drugs are usually recommended to be combined with continuous positive airway pressure,the first-line treatment for OSA.In this article,we reviewed the research on OSA and HF to provide necessary references for subsequent more effective targeted treatment.

关 键 词：阻塞性睡眠呼吸暂停 心力衰竭 低氧血症 持续气道正压通气 

分 类 号：R543[医药卫生—心血管疾病]