注射抗CD20单克隆抗体后发生荨麻疹性血管炎一例  

Urticarial vasculitis after injection of anti-CD20 monoclonal antibody:a case report

作　　者：曹园园 张朝霞 刘永霞[1,2] 杨宝琦 CAO Yuanyuan;ZHANG Zhaoxia;LIU Yongxia;YANG Baoqi(Hospital for Skin Diseases,Shandong First Medical University,Jinan 250022,China;Shandong Provincial Institute of Dermatology and Venereology,Shandong Academy of Medical Sciences,Jinan 250022,China)

机构地区：[1]山东第一医科大学附属皮肤病医院,山东济南250022 [2]山东省皮肤病性病防治研究所,山东济南250022

出　　处：《中国麻风皮肤病杂志》2024年第10期730-733,共4页China Journal of Leprosy and Skin Diseases

基　　金：山东省皮肤性病学临床医学研究中心。

摘　　要：患者,女,61岁。全身皮肤泛发红斑1天。起病前7天因“红斑型天疱疮”应用抗CD20单克隆抗体治疗。用药后躯干、四肢泛发水肿性红斑。结合组织病理诊断为荨麻疹性血管炎。给予甲泼尼龙、氯雷他定等治疗,4天后患者皮疹逐渐消退,原有红斑部位可见色素沉着斑。随访8个月,皮疹未复发。A 61-year-old female presented with erythema all over the body for 1 day.The patient was treated with anti-CD20 monoclonal antibody for“pemphigus erythematosus”7 days ago.Clinical manifestations combined with pathology,the diagnosis of urticarial vasculitis was made.The patient was treated with methylprednisolone and loratadine,and the rash gradually subsided after 4 days.Pigmentation spots were seen in the original erythema.The patient was followed up for 8 months,and the rash did not recur.

关 键 词：抗CD20单克隆抗体 荨麻疹性血管炎 

分 类 号：R758.24[医药卫生—皮肤病学与性病学]