呼吸道合胞病毒感染诱导哮喘发病机制及中医药防治进展  

Pathogenesis of Respiratory Syncytial Virus Infection-Induced Asthma and Progress in Its Prevention and Treatment with Traditional Chinese Medicine

作　　者：朱子钰 赵霞[1] 纪建建 吴嘉宝 单祎文 严花 ZHU Ziyu;ZHAO Xia;JI Jianjian;WU Jiabao;SHAN Yiwen;YAN Hua(The Affiliated Hospital of Nanjing University of Chinese Medicine,Nanjing 210029,China)

机构地区：[1]南京中医药大学附属医院,江苏南京210029

出　　处：《南京中医药大学学报》2024年第8期855-863,共9页Journal of Nanjing University of Traditional Chinese Medicine

基　　金：国家自然科学基金面上项目(82074489);江苏省中医院高峰学术人才培养项目(Y2021rc21)。

摘　　要：呼吸道合胞病毒(Respiratory syncytial virus,RSV)感染作为反复发作性喘息的潜在易感性因素,可通过免疫损伤、气道上皮屏障损伤、气道炎症浸润、气道高反应性、诱导易感基因高表达等途径影响哮喘的发生发展。中医学认为RSV感染所致哮喘多因感邪后机体气机失调以及邪气留伏所致。通过梳理近年来RSV感染在哮喘发生发展中的作用机制及中医药干预研究,以期为未来应用中西医结合手段防治哮喘提供思路。Respiratory syncytial virus(RSV)infection is a potential susceptibility factor for recurrent wheezing,which can affect the occurrence and development of asthma through immune damage,airway epithelial barrier damage,airway inflammatory infiltration,airway hyperresponsiveness,and high expression of induced susceptibility genes.Traditional Chinese medicine believes that asthma caused by RSV infection is mostly caused by the imbalance of the body's qi after infection and the retention of evil qi.By combing the mechanism of RSV infection in the occurrence and development of asthma and the research on traditional Chinese medicine intervention in recent years,it is hoped to provide ideas for the future application of combined Chinese and Western medicine to prevent and treat asthma.

关 键 词：呼吸道合胞病毒 哮喘 发病机制 气道 中医药 感染 炎症 复方 

分 类 号：R272.6[医药卫生—中医儿科学]