金属类化合物在抗菌领域的应用现状及展望  

The Application Status and Prospect of Metal Drugs in Antibacterial Field

作　　者：李国恒 王金涛 石卫平 廖向文 LI Guoheng;WANG Jintao;SHI Weiping;LIAO Xiangwen(School of Pharmacy,Jiangxi Science and Technology Normal University,Nanchang 330013,China;Department of Traditional Chinese Medicine,The Third People's Hospital of Jingdezhen,Jingdezhen 333000,China)

机构地区：[1]江西科技师范大学药学院,江西南昌330013 [2]景德镇市第三人民医院中药科,江西景德镇333000

出　　处：《南京中医药大学学报》2024年第8期864-874,共11页Journal of Nanjing University of Traditional Chinese Medicine

基　　金：江西省教育厅科技项目重点项目(GJJ211106)。

摘　　要：金属有机络合物具有悠久的临床应用历史,在治疗高血压、皮肤感染和胃肠道疾病方面表现出显著效果。随着近年来研究的进展,金属类化合物在抗细菌感染治疗中的应用及其作用机制受到了广泛地研究。笔者以3种常用金属类化合物为例,综述了金属类化合物在抗菌领域的研究进展、作用机制,并阐述了新型含金属药物以及中药提取成分及其衍生物金属络合物的研究动态,分析了金属药物在抗菌领域的潜在优势。Metal-organic complexes have a long history of clinical application and have shown remarkable efficacy in the treatment of hypertension,skin infections and gastrointestinal diseases.In recent years,the application of metalloids in anti-bacterial infection therapy and their mechanism of action have been widely studied.In this paper,three commonly used metallodrugs are selected as examples to review the progress and mechanism of metalloids in antibacterial applications,the research of novel metal-based drugs and the metallodrugs with extracted components of traditional Chinese medicines and their derivatives,and to analyze the potential advantages of metallodrugs in the field of antibacterial.

关 键 词：金属化合物 中药金属络合物 抗菌活性 抗菌作用机制 研究进展 

分 类 号：R285.5[医药卫生—中药学]