经尿道钬激光切除术与双极等离子电切术在非肌层浸润性膀胱癌手术中的应用效果  

Application of Transurethral Holmium Laser Resection and Bipolar Plasma Resection in Non-muscular Invasive Bladder Cancer Surgery

作　　者：李铮[1] LI Zheng(The Affiliated Hospital of Xinyang Vocational and Technical College,Xinyang 464000,Henan Province,China)

机构地区：[1]信阳职业技术学院附属医院,河南信阳464000

出　　处：《罕少疾病杂志》2024年第8期99-101,共3页Journal of Rare and Uncommon Diseases

摘　　要：目的探讨经尿道钬激光切除术(HOLBT)与双极等离子电切术(TURBT)在非肌层浸润性膀胱癌(NMIBC)手术中的应用效果。方法以随机数字表法将2020年9月-2021年10月我院收治的94例NMIBC患者分为两组(n=47)。对照组和观察组分别行TURBT和HOLBT。比较两组围手术期相关指标、术前和术后1周氧化应激指标(MDA、SOD、GSH-Px)、血清肿瘤标志物(IGF-1、VEGF、IGFBP-3)水平、并发症发生率和1年内复发率。结果与对照组相比较,观察组围手术期指标均较优(P<0.05);术后1周两组MDA水平上升,SOD、GSH-Px水平下降,但与对照组相比较,观察组MDA上升和SOD、GSH-Px下降幅度均较小(P<0.05);术后1周两组IGF-1、VEGF水平降低,IGFBP-3水平上升,且与对照组相比较,观察组IGF-1、VEGF水平较低,IGFBP-3水平较高(P<0.05);与对照组(17.02%、23.40%)相比较,观察组并发症发生率(8.51%)和1年内复发率(23.40%)均较低(P<0.05)。结论相较于TURBT,对NMIBC患者给予HOLBT治疗的临床应用价值更高,有利于缩短手术和住院时间,缓解机体氧化应激反应,促使肿瘤标志物水平和并发症发生率、复发率的降低。Objective To investigate the efficacy of transurethral holmium laser resection(HOLBT)and bipolar plasma electrotomy(TURBT)in non-muscular invasive bladder cancer(NMIBC).Methods 94 patients with NMIBC admitted to our hospital from September 2020 to October 2021 were divided into two groups by random number table method(n=47).Control group and observation group received TURBT and HOLBT.The perioperative relevant indexes,oxidative stress indexes(MDA,SOD,GSH-Px)before and 1 week after surgery,serum tumor markers(IGF-1,VEGF,IGFBP-3),complication rate and recurrence rate within 1 year were compared between the two groups.Results Compared with control group,perioperative indexes of observation group were better(P<0.05).One week after surgery,the level of MDA increased and the level of SOD and GSH-Px decreased in both groups,but compared with the control group,the increase of MDA and the decrease of SOD and GSH-Px in the observation group were smaller(P<0.05).One week after surgery,IGF-1 and VEGF levels decreased and IGFBP-3 levels increased,and compared with the control group,IGF-1 and VEGF levels were lower and IGFBP-3 levels were higher in the observation group(P<0.05).Compared with the control group(17.02%and 23.40%),the complication rate(8.51%)and the recurrence rate within 1 year(23.40%)in the observation group were lower(P<0.05).Conclusion Compared with TURBT,HOLBT therapy for NMIBC patients has a higher clinical value,which is beneficial to shorten the duration of surgery and hospital stay,relieve oxidative stress,and reduce the level of tumor markers,the incidence of complications and the recurrence rate.

关 键 词：非肌层浸润性膀胱癌 经尿道钬激光切除术 双极等离子电切术 临床疗效 

分 类 号：R969.4[医药卫生—药理学]