冠心病合并睡眠呼吸暂停患者住院次数相关因素的研究  

Study on the factors related to the number of hospitalizations in patients with coronary heart disease complicated with sleep apnea

作　　者：张璿 程德梅[2] 张喜维 刘旭洋 万钧 ZHANG Xuan;CHENG Demei;ZHANG Xiwei;LIU Xvyang;WAN Jun(Office of Disease Prevention and Control,Beijing Anzhen Hospital,Capital Medical University,Beijing Institute of Heart,Lung and Blood Vessel Diseases,Beijing 100029,China)

机构地区：[1]首都医科大学附属北京安贞医院-北京市心肺血管疾病研究所疾病预防控制办公室,100029 [2]首都医科大学附属北京安贞医院-北京市心肺血管疾病研究所护理部,100029 [3]首都医科大学附属北京安贞医院-北京市心肺血管疾病研究所全科医学,100029 [4]首都医科大学附属北京安贞医院-北京市心肺血管疾病研究所呼吸与危重症医学科,100029

出　　处：《心肺血管病杂志》2024年第7期706-711,共6页Journal of Cardiovascular and Pulmonary Diseases

基　　金：北京市中医药管理局科技发展项目(BJZYYB-2023-22);北京市医管局培育项目(PZ2024008);首都医学发展科研基金全科发展专项(2023-2Y-012)。

摘　　要：目的:探讨与冠心病合并睡眠呼吸暂停的患者住院次数相关的疾病因素。方法:选取2017年5月至2021年7月,于北京市安贞医院住院并确诊冠心病合并睡眠呼吸暂停的患者1738例,根据患者自述既往住院的次数将其分为多次住院组(518例)和首次住院组(1220例),比较两组患者合并高脂血症、高血压、糖尿病、低氧血症、高尿酸血症、脂肪肝、心功能不全、低钾血症及肺部感染等合并症的临床资料,分析与此类患者住院次数相关的疾病因素。结果:多次住院组与首次住院组合并高脂血症、高血压、糖尿病、低氧血症、高尿酸血症、心功能不全及肺部感染等,差异有统计学意义(P<0.05),其中多次住院组合并高血压、糖尿病、低氧血症、高尿酸血症、心功能不全、肺部感染的比例高于首次住院组[(80.7%vs.72.8%)、(45.9%vs.37.2%)、(19.7%vs.12.7%)、(11.8%vs.8.4%)、(23.7%vs.15.9%)、(5.0%vs.2.7%)],合并高脂血症的比例低于首次住院组(73.6%vs.81.3%)。Logistic回归分析结果显示,高脂血症、高血压、糖尿病、低氧血症、心功能不全是与冠心病合并睡眠呼吸暂停患者多次住院相关的疾病因素(均P<0.05)。结论:本研究表明高脂血症、高血压、糖尿病、低氧血症、心功能不全是与冠心病合并睡眠呼吸暂停患者多次住院相关的疾病因素,要加强患者出院后此类合并症的长期随诊和管理工作。Objective:To explore the disease factors related to the number of hospitalizations in patients with coronary heart disease and sleep apnea.Methods:A total of 1738 patients with coronary heart disease complicated with sleep apnea who were hospitalized in Beijing Anzhen Hospital from May 2017 to July 2021 were selected and divided into multiple hospitalization group(518 cases)and first hospitalization group(1220 cases)according to the number of hospitalizations.The clinical data of patients with hyperlipidemia,hypertension,diabetes,hypoxemia,hyperuricemia,fatty liver,cardiac insufficiency,hypokalemia,pulmonary infection and other complications were compared between the two groups,and the disease factors related to the number of hospitalizations were analyzed.Results:There were significant differences in the incidence of hyperlipidemia,hypertension,diabetes,hypoxemia,hyperuricemia,cardiac insufficiency and pulmonary infection between the multiple hospitalization group and the first hospitalization group(all P<0.05).The proportion of hypertension,diabetes,hypoxemia,hyperuricemia,cardiac insufficiency and pulmonary infection in the multiple hospitalization group was higher than that in the first hospitalization group[(80.7%vs.72.8%)、(45.9%vs.37.2%)、(19.7%vs.12.7%)、(11.8%vs.8.4%)、(23.7%vs.15.9%)、(5.0%vs.2.7%)],and the proportion of hyperlipidemia was lower than that in the first hospitalization group(73.6%vs.81.3%).Logistic regression an alysis showed that hyperlipidemia,hypertension,diabetes,hypoxemia,and cardiac insufficiency were the disease factors associated with multiple hospitalizations in patients with coronary heart disease and sleep apnea(all P<0.05).Conclusions:This study shows that hyperlipidemia,hypertension,diabetes,hypoxemia,and cardiac insufficiency are disease factors associated with multiple hospitalizations in patients with coronary heart disease and sleep apnea.It is necessary to strengthen the long-term follow-up and management of such complications after discharge.

关 键 词：冠状动脉粥样硬化性心脏病 睡眠呼吸暂停 住院次数 合并疾病 

分 类 号：R54[医药卫生—心血管疾病]