中药单体、药对药组及复方治疗子宫内膜异位症的研究现状  

Research status of traditional Chinese medicine monomer,drug-to-drug groups and compound formula in the treatment of endometriosis

作　　者：岳斌 陈元欢 武权生 张小花 程渊 梅镐 黄灿灿 张作良 吉秀家 WU Quan-sheng;ZHANG Xiao-hua;CHENG Yuan;MEI Hao;HUANG Can-can;ZHANG Zuo-liang;JI Xiu-jia(Clinical School of Chinese Medicine,Gansu University of Traditional Chinese Medicine,Lanzhou 730000,Gansu Province,China)

机构地区：[1]甘肃中医药大学中医临床学院,甘肃兰州730000

出　　处：《中国临床药理学杂志》2024年第15期2283-2287,共5页The Chinese Journal of Clinical Pharmacology

基　　金：国家自然科学基金资助项目(81760879);国家自然科学基金地区科学基金资助项目(82260949);甘肃中医药大学科创基金资助项目(2019FPZX-2,ZYXT-20-06)。

摘　　要：子宫内膜异位症(EMs)的干预包括手术切除病灶和激素治疗,通常疗效有限且存在药物不良反应。中药具有多成分、多靶点的特点,通过干预疾病不同环节,帮助患者获得良好的临床效益。本文对三棱、莪术的现代药理学进行简单论述,深入总结中药单体与经典复方提取物及其活性成分通过信号通路在炎症、免疫系统、血管生成、激素调节等方面可能发挥的作用机制,为临床使用中药单体、药对药组及复方治疗EMs提供理论基础。Interventions for endometriosis(EMs)include surgical excision of lesions and hormonal therapy,which usually have limited efficacy and adverse drug reactions.Traditional Chinese medicine(TCM)has the multi-component and multi-target characteristics,which can help patients achieve good clinical benefits by intervening in different parts of the disease.In this paper,we briefly discuss the modern pharmacology of Sanlang and Curcuma longa,and deeply summarize the possible mechanisms of action of TCM monomer and classical compound extracts and their active ingredients through signal pathways in inflammation,immune system,angiogenesis,hormone regulation,etc.,so as to provide theoretical bases for the clinical use of TCM monomers,drug-to-drug groups and compounds in the treatment of EMs.

关 键 词：中药单体 药对药组 中药复方 子宫内膜异位症 有效成分 信号通路 

分 类 号：R28[医药卫生—中药学]