内质网-线粒体互扰在功能性消化不良中的机制及疏肝健脾类中药的干预现状  

Mechanism of endoplasmic reticulum and mitochondria interference in functional dyspepsia and intervention status of Chinese medicine for Shu Gan Jian Pi

作　　者：郭军[1] 武正权[1] 王争艳 张慧君[1] 李生财[1] 田旭东[1] GUO Jun;WU Zheng-quan;WANG Zheng-yan;ZHANG Hui-jun;LI Sheng-cai;TIAN Xu-dong(Department of Spleen and Stomach Diseases,Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730020,Gansu Province,China)

机构地区：[1]甘肃省中医院脾胃病科,甘肃兰州730020

出　　处：《中国临床药理学杂志》2024年第15期2292-2295,共4页The Chinese Journal of Clinical Pharmacology

基　　金：甘肃省科技厅自然科学基金资助项目(21JR11RA206);甘肃省中医药管理局基金资助项目(qzkp-2021-14,GZK-2019-8)。

摘　　要：胃肠动力障碍是导致功能性消化不良(FD)发生的核心因素,其特征为胃肠道神经-Cajal间质细胞-平滑肌网络的破环。肝郁脾虚病机与内质网应激(ERs)-线粒体自噬稳态失衡相似,线粒体自噬紊乱是脾虚的生物学基础,肝郁是ERs的宏观体现,调控ERs-线粒体自噬途径是防治FD的重要途径。本文从“肝脾相关”理论切入,结合胃肠动力障碍发生过程中内质网和线粒体的变化,揭示肝郁脾虚病机与ERs-线粒体自噬的相关性,阐明疏肝健脾法促胃肠动力的机制,为FD胃肠动力障碍的治疗提供新观点。Gastrointestinal dyskinesia is a central factor contributing to the development of functional dyspepsia(FD),which is characterized by the rupture of the gastrointestinal nerve-Cajal interstitial cell-smooth muscle network.Gan Yu Pi Xu are similar to endoplasmic reticulum stress(ERs)-mitochondria1l autophagy homeostasisi mi balance.Mitochondrial autophagy disorders are the biological basis of Pi Xu,and Gan Yu is the macroscopic manifestation of ERs,and regulation of ERs-mitochondrial autophagy pathway is an important way to prevent and control FD.In this paper,we start from the theory of"liver-spleen correlation",combine the changes of endoplasmic reticulum and mitochondria in the process of gastrointestinal dyskinesia,reveal the correlation between the pathogenesis of Gan Yu Pi Xu and the autophagy of ERs and mitochondria,and elucidate the mechanism of gastrointestinal dyskinesia by the method of Shu Gan Jian Pi,so as to provide a new point of view for the treatment of gastrointestinal dyskinesia in FD.

关 键 词：内质网应激 线粒体自噬 功能性消化不良 肝郁脾虚 

分 类 号：R28[医药卫生—中药学]