氧化石墨烯生物材料在经皮给药系统中的研究进展  

Research Progress on Graphene Oxide Biomaterials in Transdermal Drug Delivery System

作　　者：张鑫[1] 刘笑男 高鹏[1] ZHANG Xin;LIU Xiaonan;GAO Peng(Institute of Pharmacy,Shandong University of Traditional Chinese Medicine,Jinan 250355,China)

机构地区：[1]山东中医药大学药物研究院,济南250355

出　　处：《中国现代应用药学》2024年第13期1844-1852,共9页Chinese Journal of Modern Applied Pharmacy

基　　金：山东省重点研发计划项目(2020CXGC010505);山东省自然科学基金青年项目(ZR2023QB199);山东省高等学校“青创团队计划”(2023KJ347);山东省医药卫生科技发展计划项目(202213020603);山东省中医药科技项目(Q-2023108)。

摘　　要：氧化石墨烯有丰富的含氧活性基团、巨大的比表面积和独特的离域π电子结构,是负载生物活性分子的理想材料。利用氧化石墨烯的电热效应为提高活性分子的生物利用度提供安全有效的促透皮吸收途径;同时,它还具有生物相容性、抗菌抗炎活性、促伤口愈合活性及远红外共振效应等生物活性,因此氧化石墨烯生物材料在经皮给药系统中发挥重要作用。文章介绍了氧化石墨烯的结构、理化性质和生物活性,概述了其在药物载体、抗菌材料和伤口敷料等经皮给药系统中的应用研究,并展望其在临床医学的应用前景,希望为氧化石墨烯的生物医用研究提供新的思路。With the high-speed growing demands for biomedical materials,graphene oxide(GO)and its functional derivatives show broad application prospects in the system of drug delivery,tumor therapy and nanobiology.GO has excellent hydrophilicity and easily modified surface properties,due to a large content of oxygen-containing functional groups on the GO surface.Meanwhile,the huge specific surface areas and uniqueπ-electronic structures give GO adhesion and adsorption capacities.By means ofπ-πstacking,electrostatic interaction,hydrophobic interaction or covalent bonding,therapeutic agents can be effectively combined with GO to construct drug delivery systems.GO plays an important role in transdermal drug delivery systems due to their biocompatibility,antibacterial activity,and pro-wound healing activity.As a novel drug delivery system,GO nanomaterials can achieve targeted drug delivery,accumulate drug concentrations at the focal site,and improve drug delivery efficiency.Utilizing the promoting skin regeneration and wound healing properties of GO,several antibacterial materials and wound dressings are prepared for wound treatment.In addition,the special far-infrared resonance effect and electrothermal effect of GO result in heat and electric transfer.In other words,graphene oxide could control and promote transdermal absorption efficiency upon the stimuli of heat and electric.GO is expected to break through the limitation of low transdermal absorption rates in the transdermal drug delivery systems and achieve the purpose of enhancing the transdermal permeability of target molecules(especially macromolecules):ultimately improving bioavailability in vivo.This paper will introduce the structures,physicochemical properties,and biological activities of graphene oxide,summarize its application in transdermal drug delivery systems such as drug carriers,antibacterial materials,wound dressings and transdermal enhancers,and prospect its application in clinical medicine.We hope to provide new ideas and different point of views for

关 键 词：氧化石墨烯 经皮给药 药物载体 促透皮吸收 抗菌材料 伤口敷料 

分 类 号：R944[医药卫生—药剂学]