出 处:《中国实用医药》2024年第15期28-32,共5页China Practical Medicine
基 金:佛山市科学技术局科研项目(项目编号:20171021010172号)。
摘 要:目的探讨间隔12 h动态监测感染指标在新生儿早发型败血症(early-onset neonatal sepsis,EONS)诊断中的应用价值。方法回顾性分析120例新生儿的临床病历资料,将其中60例无严重并发症的EONS作为EONS组,60例无感染新生儿作为对照组。检测两组新生儿初次监测时和间隔12 h后感染指标[白细胞计数(WBC)、中性粒细胞百分比(NEU%)、血小板计数(PLT)、C反应蛋白(CRP)和降钙素原(PCT)]。比较两组新生儿同一时间点感染指标及两组不同时间点感染指标的变化。结果EONS组初次监测时WBC、NEU%、PLT、CRP和PCT分别为(12.5±3.2)×10^(9)/L、(60.2±7.5)%、(250±50)×10^(9)/L、(5.3±2.8)mg/L、(1.2±0.5)μg/L,与对照组初次监测时的(11.8±2.9)×10^(9)/L、(59.5±8.1)%、(248±48)×10^(9)/L、(4.7±2.6)mg/L、(1.1±0.4)μg/L比较,差异无统计学意义(P>0.05)。EONS组间隔12 h后WBC、NEU%、PLT、CRP和PCT分别为(18.5±4.3)×10^(9)/L、(75.8±8.6)%、(150±35)×10^(9)/L、(65.3±15.6)mg/L、(10.8±3.2)μg/L,与对照组间隔12 h后的(12.1±3.1)×10^(9)/L、(61.2±9.0)%、(240±55)×10^(9)/L、(5.8±3.2)mg/L、(1.0±0.3)μg/L比较差异具有统计学意义(P<0.05)。EONS组间隔12 h后WBC、NEU%、PLT、CRP和PCT与本组初次监测时比较,差异具有统计学意义(P<0.05)。对照组间隔12 h后WBC、NEU%、PLT、CRP和PCT与本组初次监测时比较,差异无统计学意义(P>0.05)。结论间隔12 h后动态监测感染指标有助于提高EONS的诊断准确性,有助于更早、更准确地诊断EONS。Objective To explore the value of dynamic monitoring of infection indicators at 12-h intervals after birth in the diagnosis of early-onset neonatal sepsis(EONS).Methods Clinical data of 120 neonates were retrospectively analyzed,including 60 EONS neonates EONS without serious complications as the EONS group and 60 neonates without infection as the control group.The indicators of infection[white blood cells(WBC),neutrophil percentage(NEU%),platelets(PLT),C-reactive protein(CRP),and procalcitonin(PCT)]were tested at admission and 12-h post-admission in both groups of neonates.Differences in each index at the same time point between the two groups of neonates and changes in each index at different time points in each of the two groups were compared.Results At admission,WBC,NEU%,PLT,CRP and PCT of the EONS group were(12.5±3.2)×10^(9)/L,(60.2±7.5)%,(250±50)×10^(9)/L,(5.3±2.8)mg/L and(1.2±0.5)μg/L,and those of the control group were(11.8±2.9)×10^(9)/L,(59.5±8.1)%,(248±48)×10^(9)/L,(4.7±2.6)mg/L and(1.1±0.4)μg/L.The difference was not statistically significant in comparison(P>0.05).At 12-h post-admission,WBC,NEU%,PLT,CRP,and PCT of the EONS group were(18.5±4.3)×10^(9)/L,(75.8±8.6)%,(150±35)×10^(9)/L,(65.3±15.6)mg/L,and(10.8±3.2)μg/L,and those of the control group were(12.1±3.1)×10^(9)/L,(61.2±9.0)%,(240±55)×10^(9)/L,(5.8±3.2)mg/L,and(1.0±0.3)μg/L.The difference was statistically significant in comparison(P<0.05).In the EONS group,WBC,NEU%,PLT,CRP and PCT at 12-h post-admission were significantly different from those at admission(P<0.05).In the control group,there was no significant difference in WBC,NEU%,PLT,CRP and PCT at admission and 12-h post-admission(P>0.05).Conclusion Dynamic monitoring of infection indication at 12-h intervals after birth can improve the diagnostic accuracy of EONS, aiding in earlier and more precise diagnosis of EONS.
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