小剂量阿司匹林联合糖皮质激素治疗 小儿过敏性紫癜的有效性及安全性探讨  

The efficacy and safety of low-dose aspirin combined with glucocorticoids in the treatment of pediatric allergic purpura

作　　者：张卫春 ZHANG Wei-chun(Chengwu County People's Hospital,Heze 274299,China)

机构地区：[1]成武县人民医院儿科一区,274299

出　　处：《中国实用医药》2024年第15期42-46,共5页China Practical Medicine

摘　　要：目的对小儿过敏性紫癜患儿使用小剂量阿司匹林联合糖皮质激素进行治疗的效果做出分析。方法102例小儿过敏性紫癜患儿作为研究对象,在随机抽样法方式下将患儿划分成常规组及研究组,每组51例。常规组患儿使用糖皮质激素治疗,研究组使用小剂量阿司匹林联合糖皮质激素治疗。比较两组患儿的治疗效果、不良反应发生率、症状消退时间、炎性因子水平、血小板参数水平、补体指标水平。结果和常规组84.31%相比,研究组治疗总有效率98.04%更高,组间具有明显差异(P<0.05)。两组不良反应发生率比较,不存在统计学意义(P>0.05)。研究组皮疹、腹痛、关节痛、肾损伤消退时间分别为(6.16±1.87)、(5.01±1.65)、(6.71±1.72)、(7.76±1.95)d,短于常规组的(8.83±2.24)、(6.68±1.78)、(8.27±1.84)、(9.49±2.44)d,组间具有明显差异(P<0.05)。治疗后,研究组白细胞介素-6、超敏C反应蛋白、肿瘤坏死因子-α分别为(23.20±3.28)ng/L、(10.16±2.86)mg/L、(27.53±3.87)fmol/ml,低于常规组的(27.94±4.48)ng/L、(13.47±3.18)mg/L、(32.29±4.93)fmol/ml,组间具有明显差异(P<0.05)。治疗后,研究组血小板计数、平均血小板体积、血小板分布宽度分别为(242.11±20.42)×10^(9)/L、(8.12±2.67)fl、(20.61±3.08)%,低于常规组的(260.44±19.98)×10^(9)/L、(10.93±2.87)fl、(24.33±3.33)%,组间具有明显差异(P<0.05)。治疗后,研究组C3、C4分别为(0.84±0.07)、(0.12±0.05)g/L,低于常规组的(1.37±0.41)、(0.41±0.16)g/L,组间具有明显差异(P<0.05)。结论为小儿过敏性紫癜患儿使用小剂量阿司匹林联合糖皮质激素进行治疗,可以改善患儿症状,减轻患儿炎性因子和补体指标水平,降低患儿血小板参数水平,疗效显著,临床应用价值较高。Objective To analyze the effect of low-dose aspirin combined with glucocorticoids in the treatment of pediatric allergic purpura.Methods A total of 102 pediatric patients with allergic purpura were selected as the study subjects.The patients were randomly divided into a conventional group and a study group,each with 51 cases.The conventional group received corticosteroid treatment,while the study group received low-dose aspirin combined with corticosteroid treatment.The treatment effects,incidence of adverse reactions,time for symptom disappearance,inflammatory factors,platelet parameters,and complement indicators were compared between the two groups.Results The total effective rate of the study group was 98.04%,which was higher than 84.31%of the conventional group,and there was a significant difference between groups(P<0.05).There was no statistical significance in the incidence of adverse reactions between groups(P>0.05).In the study group,the disappearance time of rash,abdominal pain,arthralgia and kidney injury were(6.16±1.87),(5.01±1.65),(6.71±1.72)and(7.76±1.95)d,which were shorter than(8.83±2.24),(6.68±1.78),(8.27±1.84)and(9.49±2.44)d in the conventional group,and there were significant differences between groups(P<0.05).After treatment,the levels of interleukin-6,hypersensitive C-reactive protein and tumor necrosis factor-αin the study group were(23.20±3.28)ng/L,(10.16±2.86)mg/L and(27.53±3.87)fmol/ml,which were lower than(27.94±4.48)ng/L,(13.47±3.18)mg/L and(32.29±4.93)fmol/ml in the conventional group,and there were significant differences between groups(P<0.05).After treatment,the platelet count,mean platelet volume and platelet distribution width of the study group were(242.11±20.42)×10^(9)/L,(8.12±2.67)fl and(20.61±3.08)%,which were significantly lower than(260.44±19.98)×10^(9)/L,(10.93±2.87)fl and(24.33±3.33)%of the conventional group (P<0.05). After treatment, C3 and C4 in the study group were (0.84±0.07) and (0.12±0.05) g/L, which were lower than (1.37±0.41) and (0.41±0.

关 键 词：小剂量阿司匹林 糖皮质激素 小儿过敏性紫癜 有效性 安全性 

分 类 号：R725.5[医药卫生—儿科]