瑞马唑仑在临床麻醉中的应用效果  

Application effect of remimazolam in clinical anesthesia

作　　者：郑如婷 钟帝钦 蔡文恒 ZHENG Ru-ting;ZHONG Di-qin;CAI Wen-heng(Anesthesia Department,Pengpai Memorial Hospital,Haifeng County,Shanwei 516400,China)

机构地区：[1]海丰县彭湃纪念医院麻醉科,516400

出　　处：《中国实用医药》2024年第15期105-108,共4页China Practical Medicine

摘　　要：目的探讨瑞马唑仑在临床麻醉中的应用效果。方法选取需要进行胸腔镜下肺叶切除术的患者82例,依据麻醉方式不同分为对照组与研究组,每组41例。对照组给予常规麻醉药物,研究组应用瑞马唑仑麻醉。对比两组患者麻醉诱导前后的疼痛阈值、脑电指标以及外周血超氧化物歧化酶、丙二醛水平。结果麻醉诱导后,两组的疼痛阈值较麻醉诱导前明显升高,且研究组的疼痛阈值(3.68±0.26)mA比对照组的(3.09±0.10)mA高(P<0.05)。研究组外周血超氧化物歧化酶水平(90.74±10.21)U/ml比对照组的(70.86±10.37)U/ml高,丙二醛水平(6.07±1.05)nmol/ml比对照组的(7.14±1.25)nmol/ml低(P<0.05)。麻醉诱导后10、20、30 min,两组的脑电频率均低于麻醉诱导前,波幅均高于麻醉诱导前(P<0.05)。研究组麻醉诱导后20 min的脑电频率、波幅高于对照组(P<0.05);研究组麻醉诱导后30 min的脑电频率低于对照组,波幅高于对照组(P<0.05)。结论临床麻醉中应用瑞马唑仑镇静麻醉效果理想,可以降低患者的术后急慢性疼痛感,降低术后创伤后应激反应的发生几率,值得推广应用。Objective To explore the application effect of remimazolam in clinical anesthesia.Methods A total of 82 patients requiring thoracoscopic lobectomy were selected and divided into a control group and a study group according to different anesthesia methods,each consisting of 41 patients.The control group was given conventional anesthetic drugs,and the study group was given remimazolam anesthesia.The pain threshold before and after anesthesia induction,electroencephalogram index,peripheral blood superoxide dismutase and malondialdehyde levels were compared between the two groups.Results After anesthesia induction,the pain threshold of the two groups was significantly higher than that before anesthesia induction,and the study group had higher pain threshold of(3.68±0.26)mA than(3.09±0.10)mA of the control group(P<0.05).The peripheral blood superoxide dismutase of(90.74±10.21)U/ml in the study group was higher than(70.86±10.37)U/ml of the control group,and the malondialdehyde of(6.07±1.05)nmol/ml was lower than(7.14±1.25)nmol/ml of the control group(P<0.05).At 10,20 and 30 min after anesthesia induction,the electroencephalogram frequency in both groups was lower than that before anesthesia induction,and the amplitude was higher than that before anesthesia induction(P<0.05).The electroencephalogram frequency and amplitude at 20 min after anesthesia induction in the study group were higher than those in the control group(P<0.05).The electroencephalogram frequency at 30 min after anesthesia induction in the study group was lower than that in the control group,and the amplitude was higher than that in the control group(P<0.05).Conclusion The application of remimazolam sedation has an ideal effect,which can reduce the postoperative acute and chronic pain and reduce the probability of post-traumatic stress reaction,which is worthy of promotion and application.

关 键 词：瑞马唑仑 麻醉 胸腔镜肺叶切除术 丙二醛 疼痛阈值 超氧化物歧化酶 

分 类 号：R614[医药卫生—麻醉学]