左旋甲状腺素对原发性甲减患者心肌酶谱、血脂的影响研究  

Study on effect of levothyroxine on myocardial enzyme spectrum and blood lipids of hypothyroidism patients

作　　者：马海荣 李旭 MA Hai-rong;LI Xu(Department of Endocrinology,People's Hospital of Hailar District,Hulunbeir 021000,China)

机构地区：[1]内蒙古呼伦贝尔市海拉尔区人民医院内分泌科,021000 [2]内蒙古呼伦贝尔市人民医院血管外科,021000

出　　处：《中国实用医药》2024年第15期112-114,共3页China Practical Medicine

摘　　要：目的研究原发性甲状腺功能减退(甲减)患者应用左旋甲状腺素治疗对其心肌酶谱、血脂的影响。方法选取80例原发性甲状腺功能减退患者,以计算机随机化方法分为对照组和研究组,各40例。研究组给予左旋甲状腺素口服治疗,对照组给予甲状腺片口服治疗。对比两组患者血脂指标[甘油三脂(TG)、血总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)]、心肌酶谱[肌酸磷酸激酶(CK)、α-羟基丁酸脱氢酶(HBDH)、乳酸脱氢酶(LDH)]及身体脂肪(FM)、去脂体重(FFM)及体质量指数(BMI)、体重(W)、基础代谢率(BMR)。结果治疗4周后,研究组TG(1.21±0.19)mmol/L、TC(7.83±1.45)mmol/L、LDL-C(3.32±1.05)mmol/L均显著低于对照组的(1.82±0.89)、(10.13±1.99)、(4.77±1.67)mmol/L,差异具有统计学意义(P<0.05)。治疗4周后,研究组CK(265.85±42.79)IU/L、HBDH(265.31±29.45)IU/L及LDH(279.97±31.45)IU/L均低于对照组的(329.81±39.12)、(322.74±41.86)、(349.97±41.05)IU/L,差异具有统计学意义(P<0.05)。研究组FM(17.9±4.7)kg、FFM(39.2±4.4)kg、BMI(21.1±3.4)kg/m2、BMR(5022±532)kJ、W(59.1±6.4)kg均低于对照组的(21.9±3.9)kg、(42.8±5.7)kg、(26.2±4.1)kg/m2、(5636±693)kJ、(64.5±7.9)kg,差异具有统计学意义(P<0.05)。结论对于原发性甲状腺功能减退患者,左旋甲状腺素能够有效降低患者的血脂水平,对于其心肌酶谱和FM、FFM、BMI、BMR、W也起到了一定的改善作用。Objective To study the effects of levothyroxine treatment on myocardial enzyme spectrum,blood lipids and body composition in patients with primary hypothyroidism.Methods 80 patients with primary hypothyroidism were selected,and divided all the study cases into a control group and a study group by computer randomization,each with 40 cases.The study group was given oral levothyroxine,and the control group was given oral thyroid tablets.Patients in both groups were compared in terms of lipid indices[triglyceride(TG),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C)],myocardial enzyme spectrum[creatine phosphokinase(CK),α-hydroxybutyrate dehydrogenase(HBDH),lactate dehydrogenase(LDH)]and fat mass(FM),fat free mass(FFM)and body mass index(BMI),weight(W),basal metabolic rate(BMR).Results 4 weeks after treatment,the study group had TG of(1.21±0.19)mmol/L,TC of(7.83±1.45)mmol/L and LDL-C of(3.32±1.05)mmol/L,which were significantly lower than(1.82±0.89),(10.13±1.99)and(4.77±1.67)mmol/L in the control group.The difference was statistically significant(P<0.05).4 weeks after treatment,the study group had CK of(265.85±42.79)IU/L,HBDH of(265.31±29.45)IU/L and LDH of(279.97±31.45)IU/L,which were lower than(329.81±39.12),(322.74±41.86)and(349.97±41.05)IU/L in the control group.The difference was statistically significant(P<0.05).The study group had FM of(17.9±4.7)kg,FFM of(39.2±4.4)kg,BMI of(21.1±3.4)kg/m2,BMR of(5022±532)kJ and W of(59.1±6.4)kg,which were lower than(21.9±3.9)kg,(42.8±5.7)kg,(26.2±4.1)kg/m2,(5636±693)kJ and(64.5±7.9)kg in the control group,and the difference was statistically significant(P<0.05).Conclusion For patients with primary hypothyroidism,levothyroxine can effectively reduce the patient's blood lipid level,and also play a certain role in improving the patient's myocardial enzyme spectrum,FM,FFM,BMI,BMR and W.

关 键 词：代谢异常性疾病 甲状腺功能减退 左旋甲状腺素 血脂 心肌酶谱 

分 类 号：R581.2[医药卫生—内分泌]