益气健脾化湿汤辅助治疗糖尿病肾病脾虚湿盛证临床研究  

Clinical Study on Yiqi Jianpi Huashi Decoction in Adjuvant Therapy of Diabetic Kidney Disease with Syndrome of Spleen Deficiency and Prevalence of Dampness

作　　者：王瑞生 邱明生 王磊 WANG Ruisheng;QIU Mingsheng;WANG Lei(Department of Nephrology,People's Hospital of Queshan,Queshan Henan 463200,China;Department of Nephrology,The First People's Hospital of Zhumadian,Zhumadian Henan 463000,China)

机构地区：[1]确山县人民医院肾内科,河南确山463200 [2]驻马店市第一人民医院肾内科,河南驻马店463000

出　　处：《新中医》2024年第15期82-85,共4页New Chinese Medicine

摘　　要：目的:观察益气健脾化湿汤辅助治疗糖尿病肾病(DKD)脾虚湿盛证的临床疗效及对血清转化生长因子β1 (TGF-β1)、尿结缔组织生长因子(CTGF)、连接蛋白(FN)的影响。方法:采用随机数字表法将110例DKD脾虚湿盛证患者分为观察组、对照组各55例。对照组接受常规西药治疗,观察组在对照组基础上给予益气健脾化湿汤辅助治疗,2组连续治疗1个月。比较2组临床疗效及治疗前后中医证候积分、血糖指标[空腹血糖(FBG)、餐后2 h血糖(P2hBG)、糖化血红蛋白(HbA1c)]、血清肾纤维化指标(TGF-β1、CTGF、FN)、肾功能指标[血肌酐(SCr)、肾小球滤过率(eGFR)、尿素氮(BUN)]。结果:治疗后,观察组总有效率高于对照组(P<0.05)。治疗后,2组中医证候积分、FBG、P2hBG、HbA1c、TGF-β1、CTGF、FN、SCr、BUN水平均较治疗前降低(P<0.05),eGFR水平升高(P<0.05);观察组治疗后中医证候积分、TGF-β1、CTGF、FN、SCr、BUN水平及各血糖指标均低于对照组(P<0.05),eGFR水平高于对照组(P<0.05)。结论:益气健脾化湿汤辅助治疗DKD脾虚湿盛证疗效确切,能够有效控制患者血糖水平,改善肾脏纤维化和肾功能。Objective:To observe the clinical effect of Yiqi Jianpi Huashi Decoction in the adjuvant therapy of diabetic kidney disease(DKD)with the syndrome of spleen deficiency and prevalence of dampness and its effects on transforming growth factor-β1(TGF-β1),urinary connective tissue growth factor(CTGF),and fibronectin(FN)in serum.Methods:The DKD patients with the syndrome of spleen deficiency and prevalence of dampness were divided into the observation group and the control group according to the random number table method,with 55 cases in each group.The control group received conventional western medicine,and the observation group was additionally treated with Yiqi Jianpi Huashi Decoction based on the treatment of the control group.Both groups were continuously treated for one month.Clinical effects,as well as traditional Chinese medicine(TCM)syndrome scores,blood glucose indicators[fasting blood glucose(FBG),2-hour postprandial blood glucose(P2hBG),and hemoglobin A1C(HbA1c)],serum renal fibrosis indicators(TGF-β1,CTGF,and FN),kidney function indicators[serum creatinine (SCr), estimated glomerular filtration rate (eGFR), and blood urea nitrogen (BUN)] before andafter treatment were compared between the two groups. Results:After treatment,the total effective ratein the observation group was higher than that in the control group (P<0.05). After treatment, TCMsyndrome scores and the levels of FBG, P2hBG, HbA1c, TGF- β1, CTGF, FN, SCr, and BUN in thetwo groups were reduced when compared with those before treatment (P<0.05),and the levels of eGFRwere increased (P<0.05);TCM syndrome scores,levels of TGF- β1,CTGF,FN,SCr,and BUN bloodglucose indicators in the observation group were lower than those in the control group (P<0.05),and thelevel of eGFR in the observation group was higher than that in the control group (P<0.05). Conclusion:YiqiJianpi Huashi Decoction has a definite curative effect in the adjuvant therapy of DKD with the syndrome ofspleen deficiency and prevalence of dampness, which can effectively control the

关 键 词：糖尿病肾病 脾虚湿盛 益气健脾化湿汤 血糖 肾脏纤维化 肾功能 

分 类 号：R587[医药卫生—内分泌]