翁沥通胶囊辅助治疗良性前列腺增生TURP术后临床研究  

Clinical Study on Wenglitong Capsules in Adjuvant Treatment of Benign Prostatic Hyperplasia After TURP

作　　者：谷傲峥 胡跃世[1] 赵玉浩 GU Aozheng;HU Yueshi;ZHAO Yuhao(Department of Urological Surgery,Nanyang Central Hospital,Nanyang Henan 473000,China)

机构地区：[1]南阳市中心医院泌尿外科,河南南阳473000

出　　处：《新中医》2024年第15期96-100,共5页New Chinese Medicine

摘　　要：目的:观察翁沥通胶囊辅助治疗良性前列腺增生(BPH)经尿道前列腺电切术(TURP)后患者的临床疗效。方法:选取良性BPH TURP术后患者82例,按随机数字表法分为观察组和对照组各41例。对照组术后给予常规干预及盐酸坦洛新缓释片治疗,观察组术后在对照组基础上联合翁沥通胶囊辅助治疗。评价2组临床疗效,比较2组治疗前后中医证候评分、国际前列腺症状评分(IPSS)和生活质量(QOL)评分,检测血清睾酮(T)、促黄体生成素(LH)、催乳素(PRL)水平,采用B型超声波检查前列腺大小,计算前列腺体积(PV),测定膀胱残余尿量(RV)及最大尿流量(Qmax),观察不良反应情况。结果:观察组总有效率为95.12%,高于对照组78.05%(P<0.05)。治疗后,2组IPSS评分、中医证候评分较治疗前降低,QOL评分较治疗前升高(P<0.05);且观察组IPSS评分、中医证候评分低于对照组,QOL评分高于对照组(P<0.05)。治疗后,2组PV、RV水平较治疗前降低,Qmax水平较治疗前上升(P<0.05);且观察组PV、RV水平低于对照组,Qmax水平高于对照组(P<0.05)。治疗后,2组T、PRL水平较治疗前上升,LH水平较治疗前降低(P<0.05);且观察组T、PRL水平高于对照组,LH水平低于对照组(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:翁沥通胶囊辅助治疗良性BPH TURP术后患者的临床疗效较好,能够改善症状,调节性激素水平,有利于提高患者生活质量和改善患者残余尿量、缩小前列腺体积,无明显不良反应。Objective:To observe the clinical effect of the adjuvant treatment of Wenglitong Capsules on patients with benign prostatic hyperplasia(BPH)after transurethral resection of the prostate(TURP).Methods:A total of 82 BPH patients after TURP were selected and divided into the observation group and the control group according to the random number table method,with 41 cases in each group.The control group was treated with routine interventions and Tamsulosin Hydrochloride Sustained Release Tablets after TURP,and the observation group was additionally treated with Wenglitong Capsules after TURP based on the treatment of the control group.The clinical effects in both groups were evaluated;the traditional Chinese medicine(TCM)syndrome scores,International Prostate Symptom Scores(IPSS)and scores of Quality of Life(QOL)were compared before and after treatment between the two groups;the levels of serum testosterone(T),luteinizing hormone(LH)and prolactin(PRL)were detected;the prostate size was examined by B-mode ultrasound;the prostate volume(PV)was calculated;the residual urine volume(RV) and maximum urine flow rate (Qmax) were measured,and the adverse reactions were observed. Results:The total effective rate was 95.12% in the observation group, higher than that of 78.05% in the controlgroup (P<0.05). After treatment,the IPSS and TCM syndrome scores in both groups were reduced whencompared with those before treatment, and the QOL scores were up-regulated when compared withthose before treatment (P<0.05);the IPSS and TCM syndrome scores in the observation group were lowerthan those in the control group, and the QOL score was higher than that in the control group (P<0.05).After treatment,the levels of PV and RV in both groups were dwindled when compared with those beforetreatment, and the Qmax levels were elevated when compared with those before treatment (P<0.05);the levels of PV and RV in the observation group were lower than those in the control group,and the Qmaxlevel was higher than that in the control group (P<0.05). Af

关 键 词：良性前列腺增生 翁沥通胶囊 经尿道前列腺电切术 性激素 生活质量 

分 类 号：R697.3[医药卫生—泌尿科学]