培元调神针灸法联合子午流注穴位贴敷治疗卵巢早衰临床研究  

Clinical Study on Peiyuan Tiaoshen Acupuncture and Moxibustion Method Combined with Midnight-Midday Point Application for Premature Ovarian Failure

作　　者：许江虹[1,2] 陈跃来 章晓洁 薛佳颖 XU Jianghong;CHEN Yuelai;ZHANG Xiaojie;XUE Jiaying(Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Department of Gynecology,Shanghai Jingan Hospital of Traditional Chinese Medicine,Shanghai 200072,China;Sleep Medicine Center,Longhua Hospital Shanghai University of Traditional Chinese Medicine,Shanghai 200032,China)

机构地区：[1]上海中医药大学,上海201203 [2]上海市静安区中医医院妇科,上海200072 [3]上海中医药大学附属龙华医院睡眠医学中心,上海200032

出　　处：《新中医》2024年第15期143-147,共5页New Chinese Medicine

基　　金：上海市静安区中医药临床重点专科建设项目(JA2020-Z006);上海市静安区不孕不育专病诊疗中心项目(JA2021-ZLZX001)。

摘　　要：目的:观察培元调神针灸法联合子午流注穴位贴敷治疗卵巢早衰的临床疗效及对患者卵巢体积、卵巢血流参数的影响。方法:采用随机数字表法将92例卵巢早衰患者分为对照组、治疗组各46例。对照组给予常规西药治疗,治疗组在对照组基础上给予培元调神针灸法联合子午流注穴位贴敷治疗。比较2组治疗前后中医证候积分、焦虑自评量表(SAS)评分、卵巢体积、卵泡数目、卵巢血流参数及血清性激素水平,评估2组临床疗效及不良反应发生情况。结果:治疗组总有效率91.30%,高于对照组73.91%(P<0.05)。治疗后,2组中医证候积分、SAS评分、阻力指数及血清促黄体生成激素(LH)、卵泡刺激素(FSH)水平均较治疗前降低(P<0.05),且治疗组中医证候积分、SAS评分、阻力指数及血清LH、FSH水平低于对照组(P<0.05)。治疗后,2组雌二醇(E2)水平、卵巢收缩期峰值流速、舒张末期流速较治疗前升高(P<0.05),左、右侧卵巢体积增大(P<0.05),卵泡数目增加(P<0.05),且治疗组上述指标高于对照组(P<0.05)。2组均未出现严重不良反应。结论:培元调神针灸法联合子午流注穴位贴敷治疗卵巢早衰疗效确切,能够调节患者性激素水平,改善患者卵巢血流参数,安全性较高。Objective:To observe the clinical effect of the therapy of Peiyuan Tiaoshen acupuncture and moxibustion method combined with midnight-midday point application on premature ovarian failure and its effect on ovarian volume and blood flow parameters of ovary.Methods:A total of 92 patients with premature ovarian failure were divided into the control group and the treatment group according to the random number table method,with 46 cases in each group.The control group was treated with routine western medicine,and the treatment group was additionally treated with Peiyuan Tiaoshen acupuncture and moxibustion method combined with midnight-midday point application based on the treatment of the control group.The traditional Chinese medicine(TCM)syndrome scores,Anxiety Self-Rating Scale(SAS) score, ovarian volume, number of ovarian follicles, blood flow parameters of ovary and levels of serumsex hormones between the two groups were compared before and after treatment,and the clinical effectsand incidence of adverse reactions in the two groups were evaluated. Results:After treatment,the totaleffective rate was 91.30% in the treatment group, higher than that of 73.91% in the control group (P<0.05). After treatment, the TCM syndrome scores, SAS score, resistance index and levels of serumluteinizing hormone (LH) and follicle-stimulating hormone (FSH) in the two groups were decreased whencompared with those before treatment (P<0.05),and the TCM syndrome scores,SAS score,resistanceindex and levels of serum LH and FSH in the treatment group were lower than those in the control group(P<0.05). After treatment,the levels of estradiol (E2),and peak systolic velocity and end diastolic velocityof ovary in the two groups were increased when compared with those before treatment (P<0.05);the leftand right ovarian volume was increased (P<0.05),and the number of ovarian follicles was increased (P<0.05);the above indexes in the treatment group were higher than those in the control group (P<0.05).There was no adverse reaction in the two groups

关 键 词：卵巢早衰 培元调神针灸法 子午流注穴位贴敷 性激素 卵巢血流参数 

分 类 号：R711.75[医药卫生—妇产科学]