Photo-controllable antifouling hydrogels embedded with AgNPs coated spiropyran functionalized mesoporous silica for long-term antibacterial activity  

作　　者：Wei Su Fei Wang Bing Chen Ruoke Li Jindian Liu Junjie Xu Jianhua Fan Yueling Liu 

机构地区：[1]State Key Laboratory of Bioreactor Engineering,East China University of Science and Technology,Shanghai 200237,China [2]Department of Applied Biology,School of Biotechnology,East China University of Science and Technology,Shanghai 200237,China

出　　处：《Nano Research》2024年第9期8337-8349,共13页纳米研究（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.21804043);the Funding Project of the State Key Laboratory of Bioreactor Engineering.

摘　　要：Silver nanoparticles(AgNPs)are widely used in antimicrobial applications.However,its easy aggregation and rapid loss hinder the effective antifouling.To address this issue,a novel stimuli-responsive antibacterial nanocomposite(Ag@SP-MSN)was developed based on spiropyran covalently conjugated mesoporous silica nanoparticles(284.6 nm)and AgNPs(27.1 nm)via strong electrostatic attraction.Both transmission electron microscopy(TEM)and atomic force microscopy(AFM)images proved the successful modification of AgNPs onto SP-MSN.The light-induced maximum loading amount towards AgNPs was calculated to be 95.0 wt.%after ultraviolet irradiation,while the amount of AgNPs released from Ag@SP-MSN was 94.4 wt.%under visible light in the aid of ammonia(0.1%,v/v).Upon cycled light irradiation,Ag@SP-MSN could recover 84.5 wt.%of AgNPs even after four cycles.The proposed Ag@SP-MSN exhibited better antibacterial activity against both E.coli and S.aureus than Ag@MSN under visible light illumination,indicating the efficient photo-responsive isomerization of spiropyran.Furthermore,the Ag@SP-MSN embedded gel demonstrated outstanding antifouling ability even after 21 days when compared to AgNPs gel.The long-term photo-controllable antifouling property proved the excellent reversible absorption and release of Ag@SP-MSN towards AgNPs.This work provides new insights into the safe utilization of nanomaterials,offering promising advancements to meet clinical antibacterial requirements.

关 键 词：light-responsive silver nanoparticles SPIROPYRAN mesoporous silica nanoparticles antibacterial activity 

分 类 号：O61[理学—无机化学]