乳腺增生患者供血动脉血流参数与促血管新生因子表达及综合治疗疗效的相关性  

The Correlation Among Blood Flow Parameters of the Supplying Artery,Expression of Angiogenesis Stimulating Factor,and Comprehensive Treatment Efficacy of Surgical in Patients with Breast Hyperplasia

作　　者：李夏[1] 李拓[1] 董莹 Li Xia;Li Tuo;Dong Ying(Department of Ultrasound Diagnosis,The First Affiliated Hospital of Nanyang Medical College,Nanyang,Henan 473000,China;Department of Medical Technology,Nanyang Medical College,Nanyang,Henan 473000,China)

机构地区：[1]南阳医学高等专科学校第一附属医院超声诊断科,河南省南阳市473000 [2]南阳医学高等专科学校医学技术系,河南省南阳市473000

出　　处：《中国超声医学杂志》2024年第8期870-874,共5页Chinese Journal of Ultrasound in Medicine

摘　　要：目的 探究乳腺增生患者超声测定乳腺供血动脉血流参数[收缩期峰值流速(PSV)、阻力指数(RI)]与促血管新生因子[血管内皮生长因子(VEGF)、碱性成纤维细胞生长因子(bFGF)]表达及综合治疗疗效的相关性。方法 回顾性收集经病理证实的122例乳腺增生患者临床资料,统计对比不同病理类型、不同疗效乳腺增生患者入院次日(综合治疗前)PSV、RI及VEGF、bFGF水平,观察综合治疗前后指标变化。受试者工作特征(ROC)曲线分析治疗前PSV、RI、VEGF、bFGF对疗效的预测效能;Pearson分析评价治疗前PSV、RI与VEGF、bFGF的相关性。结果 混合型与腺瘤样增生患者PSV、RI及血清VEGF、bFGF水平均显著大于囊性增生、小叶增生(P<0.05),混合型与腺瘤样增生之间、囊性增生与小叶增生之间对比差异均无统计学意义(P>0.05)。乳腺增生患者治疗3个月后PSV、RI、血清VEGF及bFGF水平较治疗前均显著下降(P<0.05)。122例乳腺增生患者中,治疗显效率为83.61%(102/122),不佳率为16.39%(20/122)。治疗显效患者治疗前PSV[(9.75±2.20)cm/s vs.(11.25±2.33)cm/s]、RI(0.49±0.10 vs. 0.60±0.09)、血清VEGF[(206.95±27.07)ng/L vs.(240.58±43.65)ng/L]及bFGF[(42.94±8.13)ng/L vs.(50.00±12.01)ng/L]水平均显著低于不佳患者(P<0.05)。治疗前PSV、RI、VEGF、bFGF单一检测及其联合检测预测乳腺增生患者治疗显效的曲线下面积分别为0.717、0.802、0.721、0.676、0.933。乳腺增生患者治疗前PSV与VEGF、bFGF正相关(P<0.001),RI与VEGF、bFGF正相关(P<0.001)。结论 乳腺增生患者乳腺供血动脉血流参数与促血管新生因子均呈正相关,检测结果对治疗效果有一定的预测价值,特别是联合检测。Objective To explore the correlation among blood flow parameters[peak systolic velocity(PSV),resistance index(RI)] measured by ultrasonography,the level of angiogenesis stimulating factors[vascular endothelial growth factor(VEGF),basic fibroblast growth factor(bFGF)] expression and comprehensive treatment efficacy in patients with breast hyperplasia.Methods Clinical data of 122 patients with breast hyperplasia confirmed by pathology were collected retrospectively.The levels of PSV,RI,VEGF and bFGF of patients with different pathological types and different therapeutic effects were analyzed on the day after admission(before comprehensive treatment),and the index changes before and after comprehensive treatment were observed.The predictive efficacy of PSV,RI,VEGF and bFGF before treatment was analyzed by receiver operating characteristic(ROC)curve;Pearson analysis was performed to evaluate the correlation among PSV,RI,VEGF and bFGF before treatment.Results The levels of PSV,RI,serum VEGF and bFGF in patients with mixed type and adenomatous hyperplasia were significantly higher than those of cystic hyperplasia or lobular hyperplasia(P<0.05),and there was statistically non-significant between the mixed type and adenomatous hyperplasia,neither between cystic hyperplasia and lobular hyperplasia(P>0.05).The levels of PSV,RI,serum VEGF and bFGF in patients with breast hyperplasia after 3 months of treatment significantly decreased compared with those before treatment(P<0.05).In 122 cases of breast hyperplasia,the effective rate was 83.61%(102/122)and the poor response rate was 16.39%(20/122).The levels of PSV[(9.75±2.20)cm/s vs.(11.25±2.33)cm/s],RI(0.49±0.10 vs.0.60±0.09),serum VEGF[(206.95±27.07)ng/L vs.(240.58±43.65)ng/L] and bFGF[(42.94±8.13)ng/L vs.(50.00±12.01)ng/L]before treatment in the effective response group were significantly lower than those with poor response(P<0.05).Before treatment,the area under the curve of PSV,RI,VEGF and bFGF and their combined detection were 0.717,0.802,0.721,0.676 and 0.933,r

关 键 词：乳腺增生 彩色多普勒超声 血流参数 促血管新生因子 疗效 相关性 

分 类 号：R445.1[医药卫生—影像医学与核医学] R655.8[医药卫生—诊断学]