基于反溶剂结晶法制备姜黄素纳米微粉  

Preparation of Curcumin Nanopowder Based on Antisolvent Crystallization Method

作　　者：柴宝丽[1] 苏适[1] 申钰佳 Chai Baoli;Su Shi;Shen Yujia(Suihua University,Suihua,Heilongjiang 152061)

机构地区：[1]绥化学院食品与制药工程学院,黑龙江绥化152061

出　　处：《绥化学院学报》2024年第8期152-156,共5页Journal of Suihua University

基　　金：黑龙江省大学生创新创业训练项目(202010236010);药食同源特色产品开发与应用创新团队(SIT05005)。

摘　　要：为了研究和确定反溶剂结晶法制备姜黄素纳米微粉的处方及工艺,文章以粒径、释放曲线、收率等为考察指标,确定溶剂种类、溶液浓度、搅拌方式、溶剂反溶剂体积比、反应温度、喷液速度、表面活性剂种类、放置时间等参数,通过正交试验对处方进行优化,并进行高温、高湿及光照试验,验证纳米微粉的稳定性。结果显示最佳工艺是姜黄素乙醇溶液浓度为5 mg/mL,以Poloxamer188的水溶液作为反溶剂,溶剂与反溶体积比为1:5,反溶剂55℃,以1.0 mL/min喷入姜黄素溶液,以超声振荡器进行混合,混匀后放置8h,分离,减压干燥;稳定性试验结果表明,纳米微粉在高温及光照条件下性状及释放性能稳定,高湿条件下易结块,释放度显著降低。To explore and determine the formula and process for preparing curcumin nanopowder by antisolvent crystallization method.Particle size,release curve,yield,etc.are used as inspection indicators to determine parameters such as solvent type,solution concentration,stirring method,solvent to anti-solvent volume ratio,reaction temperature,spray speed,surfactant type,and placement time.The formula is optimized through orthogonal experiments,and high temperature,high humidity and light tests are conducted to verify the stability of the nanopowder.The optimal process are as follows:the concentration of curcumin ethanol solution is 5 mg/mL,the aqueous solution of Poloxamer 188 is used as the anti-solvent,the volume ratio of solvent to anti-solvent is 1:5,and the anti-solvent is 55℃.The curcumin solution is sprayed at 1.0 mL/min,mixed with an ultrasonic oscillator,leaving it for 8 hours after mixing evenly,to separate,and dry under reduced pressure.Stability test results show that the properties and release performance of nanopowder are stable under high temperature and light conditions,but are easy to agglomerate under high humidity conditions and the release degree is significantly reduced.

关 键 词：姜黄素 纳米微粉 制备工艺 释放度 稳定性 

分 类 号：TQ460[化学工程—制药化工]