Electrochemical protein biosensors for disease marker detection:progress and opportunities  

作　　者：Lanpeng Guo Yunong Zhao Qing Huang Jing Huang Yanbing Tao Jianjun Chen Hua-Yao Li Huan Liu 

机构地区：[1]School of Integrated Circuits,Wuhan National Laboratory for Optoelectronics,Optics Valley Laboratory,Huazhong University of Science and Technology,Wuhan 430074,China [2]Key Laboratory of Intelligent Computing and Signal Processing of Ministry of Education,School of Integrated Circuits,Anhui University,Hefei 230601,China [3]School of Optoelectronic Materials and Technology,Jianghan University,Wuhan 430056,China [4]Department of Otorhinolaryngology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,1277 Jiefang Avenue,Wuhan 430022,China [5]Wenzhou Institute of Advanced Manufacturing Technology,Huazhong University of Science and Technology,Wenzhou 325000,China

出　　处：《Microsystems & Nanoengineering》2024年第3期1-20,共20页微系统与纳米工程（英文）

基　　金：supported by the Hubei Provincial Natural Science Foundation of China(Grant No.2022CFA035);the Zhejiang Provincial Natural Science Foundation of China(Grant No.Y23F040019).

摘　　要：The development of artificial intelligence-enabled medical health care has created both opportunities and challenges for next-generation biosensor technology.Proteins are extensively used as biological macromolecular markers in disease diagnosis and the analysis of therapeutic effects.Electrochemical protein biosensors have achieved desirable specificity by using the specific antibody–antigen binding principle in immunology.However,the active centers of protein biomarkers are surrounded by a peptide matrix,which hinders charge transfer and results in insufficient sensor sensitivity.Therefore,electrode-modified materials and transducer devices have been designed to increase the sensitivity and improve the practical application prospects of electrochemical protein sensors.In this review,we summarize recent reports of electrochemical biosensors for protein biomarker detection.We highlight the latest research on electrochemical protein biosensors for the detection of cancer,viral infectious diseases,inflammation,and other diseases.The corresponding sensitive materials,transducer structures,and detection principles associated with such biosensors are also addressed generally.Finally,we present an outlook on the use of electrochemical protein biosensors for disease marker detection for the next few years.

关 键 词：diagnosis SPECIFICITY ELECTROCHEMICAL 

分 类 号：TP212[自动化与计算机技术—检测技术与自动化装置]