中药活性成分调控糖代谢抗胆管癌的分子机制  

Molecular mechanism of traditional Chinese medicine active components in regulating glucose metabolism against cholangiocarcinoma

作　　者：赵方言 李姗[2] 王祥麒[3] 尹怡[3] ZHAO Fangyan;LI Shan;WANG Xiangqi;YIN Yi(The Third Clinical Medical College,Henan University of Chinese Medicine,Zhengzhou 450046,China;School of Medicine,Henan University of Chinese Medicine,Zhengzhou 450046,China;Department of Oncology,The Third Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450046,China)

机构地区：[1]河南中医药大学第三临床医学院,郑州450046 [2]河南中医药大学医学院,郑州450046 [3]河南中医药大学第三附属医院肿瘤科,郑州450046

出　　处：《临床肝胆病杂志》2024年第8期1704-1708,共5页Journal of Clinical Hepatology

基　　金：河南省中医药科学研究专项课题(2023ZY2110);河南省高等学校青年骨干教师资助项目(2021GGJS084)。

摘　　要：胆管癌是一种高度异质性的肿瘤,其发病隐匿、病情凶险、恶性程度高、预后极差。葡萄糖是胆管癌增殖和转移的主要能量来源,胆管癌细胞在快速增殖过程中其糖代谢途径会被重新编辑,产生大量能量以满足自身需求。中医药在胆管癌治疗中具有独特优势,中药活性成分已被证明可以通过调控糖代谢抑制胆管癌的发生和发展。本文对胆管癌中的糖代谢特点和中药活性成分调控糖代谢抗胆管癌进行综述,为胆管癌的治疗提供新思路。Cholangiocarcinoma is a highly heterogeneous tumor with an insidious onset,severe conditions,a high degree of malignancy,and an extremely poor prognosis.Glucose is a major energy source for the proliferation and metastasis of cholangiocarcinoma,and the glucose metabolism pathway of cholangiocarcinoma cells will be re-edited in the process of rapid proliferation to produce a large amount of energy for their own needs.Traditional Chinese medicine has unique advantages in the treatment of cholangiocarcinoma,and studies have shown that the active components of traditional Chinese medicine can inhibit the development and progression of cholangiocarcinoma by regulating glucose metabolism.This article reviews the characteristics of glucose metabolism in cholangiocarcinoma and the role of the active components of traditional Chinese medicine in regulating glucose metabolism against cholangiocarcinoma,in order to provide new ideas for the treatment of cholangiocarcinoma.

关 键 词：胆管肿瘤 碳水化合物代谢 中药 药理作用分子作用机制(中药) 

分 类 号：R285[医药卫生—中药学]