CCN家族蛋白在糖尿病肾病中的作用  

The role of CCN family proteins in diabetes nephropathy

作　　者：陈瑶 魏佳莉[1] CHEN Yao;WEI Jiali(Department of Nephrology,Hainan Provincial People's Hospital/Affiliated Hainan Hospital of Hainan Medical University,Haikou570311,China)

机构地区：[1]海南省人民医院/海南医科大学附属海南医院肾内科,海南海口570311

出　　处：《海南医学院学报》2024年第16期1271-1275,1280,共6页Journal of Hainan Medical University

基　　金：国家自然科学基金资助项目(82160135)。

摘　　要：糖尿病肾脏疾病(DKD)是一类以进行性肾组织纤维化为特征的肾脏疾病。在明确糖尿病为肾损害病因并排除其他原因引起的慢性肾脏病(CKD)前提下,1型和2型糖尿病患者出现持续性白蛋白尿,或估算肾小球滤过率进行性下降大于3个月,或肾活检符合DKD病理诊断,可诊断为DKD。细胞通讯网络(CCN)家族蛋白是一组细胞间基质蛋白,参与调解生长、凋亡、衰老、自噬、迁移、分化和炎症等重要细胞病理生理改变。新近研究显示,CCN家族蛋白在DKD大鼠肾脏模型中表达显著上调,提示其在DKD肾小管上皮细胞发生上皮-间充质转化(EMT)和肾间质纤维化进展中发挥重要作用。本文综述了CCN家族蛋白介导DKD肾脏损伤的作用及机制,以探索DKD潜在的治疗靶点。Diabetes kidney disease(DKD)is a kind of kidney disease characterized by progressive renal tissue fibrosis.On the premise that diabetes is the cause of kidney damage and chronic kidney disease(CKD)caused by other reasons is excluded,type 1 and type 2 diabetes patients can be diagnosed with DKD if they have persistent albuminuria,or if the estimated glomerular filtra⁃tion rate has declined for more than 3 months,or if renal biopsy conforms to the pathological diagnosis of DKD.The cell communi⁃cation network(CCN)family of proteins is a group of intercellular matrix proteins involved in regulating important cellular patho⁃physiological changes such as growth,apoptosis,aging,autophagy,migration,differentiation,and inflammation.Recent studies have shown that the CCN family proteins are significantly upregulated in the DKD rat kidney model,suggesting that they play an important role in the epithelial-mesenchymal transition(EMT)of DKD renal tubular epithelial cells and the progression of renal in⁃terstitial fibrosis.This article reviews the role and mechanism of CCN family proteins in mediating renal injury in DKD,in order to explore potential therapeutic targets for DKD.

关 键 词：CCN家族蛋白 糖尿病肾病 上皮-间充质转化 肾纤维化 

分 类 号：R587.2[医药卫生—内分泌] R692.9[医药卫生—内科学]