子痫前期的中药临床应用与现代药理学进展  

Clinical Application and Modern Pharmacological Progress of Traditional Chinese Medicine in Preeclampsia

作　　者：任毅 胡玉莲[2] 王新 张琦 刘超[3] 高慧婕[3] REN Yi;HU Yu-lian;WANG Xin;ZHANG Qi;LIU Chao;GAO Hui-jie(College of Pharmacy,Binzhou Medical University,Yantai 264000,Shandong Province,China;Department of Obstetrics and Gynecology,People's Hospital of Rizhao,Rizhao 276826,Shandong Province,China;College of Pharmacy,Jining Medical University,Rizhao 276826,Shandong Province,China;College of Pharmacy,Shandong First Medical University,Jinan 271000,China)

机构地区：[1]滨州医学院药学院,山东省烟台市264000 [2]日照市人民医院妇产科 [3]济宁医学院药学院 [4]山东省第一医科大学药学院

出　　处：《国际妇产科学杂志》2024年第4期442-447,共6页Journal of International Obstetrics and Gynecology

基　　金：山东省自然科学基金(ZR2021MH164);济宁医学院贺林院士新医学临床转化工作站科研基金(JYHL2021MS08)。

摘　　要：子痫前期是一种妊娠特异性疾病,临床以妊娠20周后出现高血压、蛋白尿等症状为主要特征,子痫前期严重危害母婴生命健康,是导致孕产妇和围产儿死亡率增高的重要因素之一。近年来,采用中药汤剂、活血化瘀类中药注射液等治疗子痫前期的研究增多,取得了良好的临床疗效。现代药理学研究发现,葛根素、天麻素、钩藤碱、人参皂苷、白术内酯、丹参素、川芎嗪、黄芪甲苷等成分能够促进滋养细胞增殖和侵袭,改善实验动物妊娠过程,对子痫前期的治疗起到积极作用。梳理相关文献,通过结合临床疗效与机制研究,分析中药临床用药合理性,为中药防治子痫前期的临床应用与开发提供参考。Preeclampsia is a pregnancy-related disease clinically characterized by high blood pressure and proteinuria after 20 weeks of gestation.Preeclampsia is a serious danger to the life and health of mothers and infants,and is one of the main causes of maternal and perinatal mortality.For the past few years,multiple Chinese herbal formulas and Chinese medicine injections have been shown to prevent and treat preeclampsia,and good clinical efficacy has been achieved.Modern pharmacological studies have found that Puerarin,Gastrodin,Rhynchophylline,Ginsenoside,Atractylenolide,Danshensu,Tetramethylpyrazine,Astragaloside can promote trophoblast proliferation and invasion,improve the process of pregnancy in experimental animals and play a positive role in the treatment of preeclampsia.Through the relevant literature and analysed the rationality of the clinical use of traditional Chinese medicines by combining clinical efficacy and mechanism studies,this research aims to accelerate and promote the clinical application and development of traditional Chinese medicine in the prevention and treatment of preeclampsia.

关 键 词：先兆子痫 滋养细胞 治疗结果 中药 药理学 

分 类 号：R285.6[医药卫生—中药学]