中药有效成分结合生物材料在骨组织工程中作用的研究进展  

Advances in the role of effective components of traditional Chinese medicine combined with biomaterials in bone tissue engineering

作　　者：万周程 钟章锋 钟侨霖[3] 王景浩 刘婷[6] 王华军 郑小飞[1] Wan Zhoucheng;Zhong Zhangfeng;Zhong Qiaolin;Wang Jinghao;Liu Ting;Wang Huajun;Zheng Xiaofei(Department of Sports Medicine,Guangzhou Key Laboratory of Precision Orthopaedics and Regenerative Medicine,Guangdong Provincial Key Laboratory of Speed Ability Research,Guangzhou 510630,China;State Key Laboratory of Traditional Chinese Medicine Quality Research,Macao University of Science and Technology,College of Traditional Chinese Medicine,Macao University of Science and Technology,Macao 999078,China;College of Traditional Chinese Medicine,Chinese University of Hong Kong,Hong Kong 999077,China;Department of Pharmaceutical,First Affiliated Hospital of Jinan University,National Key Laboratory of Cardiovascular Diseases in Cold Region,Guangzhou Key Laboratory of Basic Research and Transformation of Chronic Diseases,Guangzhou 510630,China;Harbin Medical University School of Pharmacy,Harbin 150081,China;College of Chemistry and Materials,Jinan University,Guangzhou 510630,China)

机构地区：[1]暨南大学附属第一医院运动医学科,广州市精准骨科与再生医学重点实验室,广东省速度能力研究重点实验室,广州510630 [2]澳门科技大学中药质量研究国家重点实验室,澳门科技大学中医药学院,中国澳门999078 [3]香港中文大学中医学院,中国香港999077 [4]暨南大学附属第一医院药学部,寒地心血管病全国重点实验室,广州市慢病基础研究与转化重点实验室,广州510630 [5]哈尔滨医科大学药学院,150081 [6]暨南大学化学与材料学院,广州510630

出　　处：《中华细胞与干细胞杂志（电子版）》2024年第4期249-253,共5页Chinese Journal of Cell and Stem Cell（Electronic Edition）

基　　金：中央高校基本科研业务费专项资金资助(21623119,21623319,21621103);国家自然科学基金面上项目(82172440,82074511);广州市重点项目(202201020087,2023A03J0566,SL2023A03J01128,SL2023A04J01317);广东省速度能力研究重点实验室开放基金资助项目(2023B1212010009);广东省医学科学技术研究基金项目(A2023143);暨南大学医学联合基金资金资助项目(YXJC2022005)。

摘　　要：骨组织工程是快速发展的领域,开发新型生物材料,修复受损或患病的骨组织是其主要研究方向之一。许多中药有效成分对细胞的增殖、分化以及组织或器官的修复和再生等具有重要的促进作用,将中药有效成分添加到骨科生物材料中可以提高材料的治疗效果。因此中药有效成分在骨科生物材料中的应用引起国内外研究者的关注,本文综述了中药有效成分在骨组织工程中的作用,包括促进成骨、保护及修复软骨、促血管形成和抗炎等。Bone tissue engineering is a rapidly developing field aimed at developing new biomaterials to repair damaged or diseased bone tissue.Many effective components of traditional Chinese medicine play an important role in promoting cell proliferation,differentiation,repair and regeneration of tissues or organs.Adding effective components of traditional Chinese medicine to orthopedic biomaterials can improve the therapeutic effect of materials.Therefore,the application of effective components of traditional Chinese medicine in orthopedic biomaterials has attracted the attention of researchers at home and abroad.This paper reviews the role of effective components of traditional Chinese medicine in bone tissue engineering,including promoting osteogenesis,protecting and repairing cartilage,promoting angiogenesis,anti-inflammatory.

关 键 词：中药 生物材料 骨组织工程 骨再生 软骨修复 

分 类 号：R318[医药卫生—生物医学工程]