双花坤孕方配合孕三烯酮对子宫内膜异位症患者血清CD44及TNF-α的影响  

Shuanghua Kunyun Formula combined with gestrinone to treat endometriosis and its influence on serum CD44 and TNF-αlevels

作　　者：卢青玉 贾红伟 LU Qingyu;JIA Hongwei(Department of Gynecology,Hebei Academy of Traditional Chinese Medicine,Hebei,Shijiazhuang 050011,China;不详)

机构地区：[1]河北省中医药科学院妇科,050011 [2]河北省石家庄市中医院

出　　处：《河北医药》2024年第16期2484-2487,共4页Hebei Medical Journal

基　　金：河北省中医药管理局科研计划项目(编号:2019100)。

摘　　要：目的探讨双花坤孕方配合孕三烯酮对子宫内膜异位症患者血清CD44及TNF-α的影响。方法选择2022年5月至2023年4月,收治的90例子宫内膜异位症患者,随机分为对照组和观察组,每组45例。对照组给予孕三烯酮治疗,观察组给予双花坤孕方配合孕三烯酮治疗。比较2组治疗前后免疫功能情况;比较2组治疗前后性激素水平变化情况;比较2组治疗前后血清CD44及TNF-α水平变化情况;比较2组疗效症状评分及不良反应情况。结果治疗后,2组血清IgA、Ig G、IgM水平均降低(P<0.05),且观察组更明显(P<0.05);治疗后,2组促卵泡激素(FSH)、黄体生成素(LH)、孕酮(P)、雌二醇(E2)水平均降低(P<0.05),且观察组更明显(P<0.05);治疗后,2组血清CD44及TNF-α水平均下降,且观察组更明显(P<0.05);观察组疗效优于对照组(P<0.05)。观察组症状评分及总分均低于对照组(P<0.05)。2组患者药物不良反应无明显差异(P>0.05)。结论对子宫内膜异位症患者给予双花坤孕方配合孕三烯酮治疗,可提高免疫力,改善异常的性激素水平,降低血清CD44及TNF-α水平,改善临床症状,疗效显著,且安全可靠。Objective To explore the effect of Shuanghua Kunyun Formula combined with gestrinone on serum cluster of differentiation 44(CD44)and tumor necrosis factor-alpha(TNF-α)in patients with endometriosis.Methods A total of 90 patients with endometriosis admitted to our hospital from May 2022 to April 2023 were randomly assigned into the control group(n=45)and observation group(n=45).Patients in the control group were treated with gestrinone,and those in the observation group were treated with Shuanghua Kunyun Formula combined with gestrinone.Immune function of the two groups before and after treatment was compared.Serum CD44 and TNF-αlevels before and after treatment were compared between the two groups.Efficacy and adverse events were compared between the two groups.Results After treatment,serum follicle-stimulating hormone(FSH),estrogen(P)and estradiol(E2)in both groups significantly decreased,which were significantly lower in the observation group than those of control group(P<0.05).After treatment,serum CD44 and TNF-αlevels in both groups significantly decreased,which were significantly lower in the observation group than those of control group(P<0.05).The therapeutic effect of the observation group was significantly better than that of the control group(P<0.05).There was no significant difference in the incidence of adverse drug reactions between the two groups(P>0.05).Conclusion Shuanghua Kunyun Formula combined with gestrinone improves the immune function and lowers serum CD44 and TNF-αlevels in patients with endometriosis,with high efficacy and safety.

关 键 词：双花坤孕方 孕三烯酮 子宫内膜异位症 CD44 TNF-Α 

分 类 号：R711.71[医药卫生—妇产科学]