葛根芩连汤加味联合西药治疗儿童轮状病毒性肠炎湿热证临床研究  

Clinical Study on Modified Gegen Qinlian Decoction Combined with Western Medicine for Children with Rotavirus Enteritis with Damp-Heat Syndrome

作　　者：窦景锐 张花花 杨颖 DOU Jingrui;ZHANG Huahua;YANG Ying(Gaoling Maternal and Child Health Hospital,Shanxi Xi'an 710200,China;Xijing Hospital of Air Force Medical University,Shanxi Xi'an 710032,China)

机构地区：[1]西安市高陵区妇幼保健院,陕西西安710200 [2]空军军医大学西京医院,陕西西安710032

出　　处：《新中医》2024年第14期20-24,共5页New Chinese Medicine

摘　　要：目的:观察葛根芩连汤加味联合西药治疗儿童轮状病毒性肠炎湿热证的临床疗效,以及对心肌酶谱的影响。方法:选取180例轮状病毒性肠炎湿热证患儿,依照随机数字表法分为对照组和观察组,每组90例。对照组给予西药对症治疗,观察组在对照组基础上给予葛根芩连汤加味治疗,2组均治疗5 d。比较2组临床疗效、症状消失时间,以及治疗前后心肌酶谱指标水平、中医证候积分。结果:治疗5 d后,观察组总有效率94.44%,高于对照组84.44%,差异有统计学意义(P<0.05)。观察组腹泻消失、退热、呕吐消失、脱水消失及粪便RV转阴时间均短于对照组,差异均有统计学意义(P<0.05)。治疗5 d后,2组血清肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、谷草转氨酶(AST)、乳酸脱氢酶(LDH)、α-羟丁酸脱氢酶(α-HBDH)水平均较治疗前降低,观察组上述5项心肌酶谱指标水平均低于对照组,差异均有统计学意义(P<0.05)。治疗5 d后,2组大便频数、脘腹胀满、口渴烦躁、神疲乏力、食欲不振积分均较治疗前降低,观察组上述5项中医证候积分均低于对照组,差异均有统计学意义(P<0.05)。结论:葛根芩连汤加味联合西药治疗能够快速缓解轮状病毒性肠炎湿热证患儿的症状和体征,缩短病程,减轻心肌损害。Objective:To observe the clinical effect of modified Gegen Qinlian Decoction combined with western medicine for children with rotavirus enteritis with damp-heat syndrome,as well as its effect on myocardial enzymes.Methods:A total of 180 cases of children with rotavirus enteritis with damp-heat syndrome were selected and divided into the control group and the observation group according to the random number table method,with 90 cases in each group.The control group received symptomatic treatment with western medicine,and the observation group received modified Gegen Qinlian Decoction based on the treatment of the control group.Both groups were treated for five days.The levels of myocardial enzymes and traditional Chinese medicine(TCM)syndrome scores before and after treatment as well as the clinical effects and symptom disappearance time were compared between the two groups.Results:After five days of treatment,the total effective rate was 94.44%in the observation group,higher than that of 84.44%in the control group,the difference being significant(P<0.05).The disappearance time of diarrhea,fever,vomiting,dehydration,and negative conversion time of fecal RV in the observation group were shorter than those in the control group,differences being significant(P<0.05).After five days of treatment,the levels of creatine kinase(CK),creatine kinase-MB(CK-MB),aspartate aminotransferase(AST),lactate dehydrogenase(LDH),andα-hydroxybutyrate dehydrogenase(α-HBDH)in serum in the two groups were decreased when compared with those before treatment,and the levels of the above five myocardial enzyme indicators in the observation group were lower than those in the control group,differences being significant(P<0.05).After five days of treatment,the frequency of bowel movements,bloating in the epigastric region,thirst and restlessness,fatigue and lack of strength,and loss of appetite in the two groups were decreased when compared with those before treatment,and the above five TCM syndrome scores in the observation group were lower th

关 键 词：轮状病毒性肠炎 儿童 湿热证 葛根芩连汤 心肌酶谱 中医证候 

分 类 号：R725.7[医药卫生—儿科]