氨甲苯酸注射液药物利用评价标准的建立与应用  

Establishment and Application of Drug Utilization Evaluation Criteria for Aminomethylbenzoic Acid Injection

作　　者：刘潺 廖承科 郭思彤[2] 黄海英[1] 张进华 LIU Chan;LIAO Chengke;GUO Sitong;HUANG Haiying;ZHANG Jinhua(Dept.of Clinical Pharmacy,the People’s Hospital of Liuyang,Hunan Liuyang 410300,China;Dept.of Pharmacy,People’s Hospital of Guangxi Zhuang Autonomous Region,Nanning 530016,China;Dept.of Pharmacy,Fujian Provincial Maternity and Children’s Hospital,Fuzhou 350005,China)

机构地区：[1]浏阳市人民医院临床药学科,湖南浏阳410300 [2]广西壮族自治区人民医院药学部,南宁530016 [3]福建省妇幼保健院药剂科,福州350005

出　　处：《中国医院用药评价与分析》2024年第7期853-855,共3页Evaluation and Analysis of Drug-use in Hospitals of China

基　　金：湖南省卫生健康委科研计划课题(No.D202313016463);湖南省教育厅科学研究项目(No.21C0886)。

摘　　要：目的:建立氨甲苯酸注射液药物利用评价(DUE)标准,为临床合理应用氨甲苯酸注射液提供科学的参考。方法:通过构建DUE标准的基本内容,结合专家咨询法以及国内外相关指南和文献,制订氨甲苯酸注射液DUE标准。采用回顾性研究方法,对2022年1—6月湖南省某三级医院氨甲苯酸注射液的用药合理性进行评价,具体包括适应证、用法与用量、联合用药、禁忌证、不良反应监测等。结果:建立的氨甲苯酸注射液DUE标准分为三级,包括一级指标3项、二级指标9项以及三级指标28项。共纳入500例使用氨甲苯酸注射液的患者,完全符合评价标准的有169例,合理用药率为33.80%;不完全符合的有331例,不合理用药率为66.20%,常见于适应证不适宜(233例,占70.39%)、用法与用量不适宜(222例,占67.07%)。结论:本研究建立的氨甲苯酸注射液的DUE标准具有较强的科学性、实用性和可行性,评价过程易操作、结果全面直观,可用于临床规范合理使用氨甲苯酸注射液。OBJECTIVE:To establish the drug utilization evaluation(DUE)criteria of aminomethylbenzoic acid injection,so as to provide reference for rational clinical application of aminomethylbenzoic acid injection.METHODS:By constructing the basic content of DUE criteria,based on the drug instructions of aminomethylbenzoic acid injection,referring to relevant guidelines and literature and expert consultation method,the DUE criteria of aminomethylbenzoic acid injection was established.Retrospective study was performed to evaluate the application rationality of aminomethylbenzoic acid injection in a tertiary hospital in Hunan Province from Jan.to Jun.2022,including indications,usage and dosage,drug combination,contraindications,adverse drug reactions monitoring.RESULTS:The established DUE criteria for aminomethylbenzoic acid injection were categorized into three levels,including 3 primary indicators,9 secondary indicators,and 28 tertiary indicators.A total of 500 patients using aminomethylbenzoic acid injection were included,169 cases fully met the DUE criteria,with a rational rate of 33.80%;331 cases did not fully meet the criteria,with an irrational rate of 66.20%,irrational medication was commonly found in inappropriate indications(233 cases,70.39%)and improper usage and dosage(222 cases,67.07%).CONCLUSIONS:The DUE criteria for aminomethylbenzoic acid injection established in this study are highly scientific,practical and feasible,and the evaluation process is easy to operate and the results are comprehensive and intuitive,which can be used to standardize the rational application of aminomethylbenzoic acid injection in clinical practice.

关 键 词：氨甲苯酸注射液 药物利用评价标准 合理用药 

分 类 号：R973[医药卫生—药品]