中药复方液外洗联合硫磺软膏外涂治疗马拉色菌毛囊炎临床观察  

Clinical Observation on Treating Malassezia Folliculitis by Herbal Compound Liquid for External Cleaning and Sulphur Ointment for External Application

作　　者：眭岩 魏孔熙 张强 SUI Yan;WEI Kongxi;ZHANG Qiang(The Third Affiliated Hospital of Gansu University of Chinese Medicine,Baiyin 730900,China)

机构地区：[1]甘肃中医药大学第三附属医院,甘肃白银730900

出　　处：《西部中医药》2024年第8期134-136,共3页Western Journal of Traditional Chinese Medicine

基　　金：甘肃省教育厅高等学校创新基金项目(2021B-167)。

摘　　要：目的:观察中药复方液外洗联合10%硫磺软膏外涂治疗马拉色菌毛囊炎的临床疗效。方法:将60例马拉色菌毛囊炎患者随机分为观察组与对照组,每组30例。观察组采用中药复方液外洗联合10%硫磺软膏外涂,对照组使用10%硫磺软膏外涂,连续治疗4周。观察两组临床疗效,于治疗前后采用酶联免疫吸附法测定两组患者血清白细胞介素6(interleukin-6,IL-6)、白细胞介素10(interleukin-6,IL-10)、白细胞介素18(interleukin-18,IL-18)水平,采用双抗体夹心法测定IgE抗体水平。结果:治疗后两组血清炎症因子IL-6、IL-10、IL-18水平均下降(P<0.05),且观察组降低较对照组明显(P<0.05)。治疗后两组血清IgE抗体水平较治疗前下降,观察组治疗前后比较,差异有统计学意义(P<0.05);对照组治疗前后比较,差异无统计学意义(P>0.06);治疗后观察组较对照组下降明显(P<0.05)。结论:中药复方液外洗联合10%硫磺软膏外涂,可有效治疗马拉色菌毛囊炎,可消除红肿痒痛等症状,同时可降低炎症效应及抑制过激的免疫反应。Objective:To observe therapeutic effects of external herbal compound liquid and 10%sulphur ointment for external application in the treatment of malassezia folliculitis.Methods:Sixty patients were randomly separated into the observation group and the control group with 30 cases in each group.Herbal compound liquid for external cleaning and 10%sulphur ointment for external application were administered to the observation group,and 10%sulphur ointment for external application to the control group,they were treated for four weeks consecutively.To observe clinical effects between both groups,ELISA method was adopted to detect the levels of IL-6,IL-10 and IL-18 in the two groups before and after the treatment,double-antibody sandwich ELISA was adopted to measure the levels of IgE antibody.Results:After the treatment,the levels of IL-6,IL-10 and IL-18 lowered in the two groups(P<0.05),and the decrease of the observation group was more evident than the control group(P<0.05).After treating,the levels of IgE antibodies reduced than before treating in the two groups,the difference showed statistical meaning before and after the treatment(P<0.05);the difference has no statistical meaning in the control group before and after the treatment(P<0.05);after the treatment,the observation group lowered more obviously than the control group(P<0.05).Conclusion:Herbal compound liquid for external cleaning and 10%sulphur ointment for external application could effectively treat malassezia folliculitis,relieve the symptoms including redness,swelling,itching and pain,meanwhile,reduce inflammatory effects and inhibit excessive immune response.

关 键 词：毛囊炎 马拉色菌 中药外洗 硫磺软膏 血清炎症因子 IGE抗体 

分 类 号：R275.9[医药卫生—中西医结合]