环境污染物TCDD对皮肤老化的影响  

Effects of Environmental Pollutant TCDD on Skin Aging

作　　者：武涛 刘慧 于丽娟 陈博文 庄开颜 王学文 刘菲 杨素珍 WU Tao;LIU Hui;YU Li-juan;CHEN Bo-wen;ZHANG Kai-yan;WANG Xue-wen;LIU Fei;YANG Su-zhen(Shandong Freda Biotech Co.,Ltd,Jinan Shandong 250101,china)

机构地区：[1]山东福瑞达生物股份有限公司,山东济南250101

出　　处：《环境科学导刊》2024年第4期60-64,共5页Environmental Science Survey

摘　　要：2,3,7,8-四氯二苯并对二恶英(TCDD)是一类具有代表性的环境污染物,对皮肤具有一定的毒性影响。探究其对人体皮肤老化的潜在影响,通过SwissTargetPrediction预测了TCDD的潜在毒理靶点。基于OMIM数据库和Genecards数据库收集人体皮肤老化的相关靶点,利用R软件分析TCDD影响人体皮肤老化的毒理靶点。针对此类靶点,通过STRING进行蛋白互作分析,利用metascape数据库进行GO和KEGG分析。结果表明,获取到TCDD与皮肤老化的相关毒理靶点81个,核心毒理靶点主要是MMP-1、MMP-9和EGFR等,毒理通路涉及到神经活性配体-受体相互作用、钙信号途径和IL-17炎症信号通路等。因此,环境污染物TCDD对人体皮肤有害,可通过调控多靶点、多通路加速皮肤老化。2,3,7,8-tetrachlorodibenzo-p-dioxin(TCDD)is a kind of representative environmental pollutant,which has certain toxic effects on the skin.This study explored the potential effects of TCDD on human skin aging.The potential toxicological targets of TCDD were predicted by Swiss Target Prediction database.The related targets of human skin aging were collected based on OMIM database and GeneCardsdatabase,moreover the toxicological targets of TCDD affecting human skin aging were analyzed by R software.For the above targets,protein interaction analysis was performed by STRING,and GO and KEGG were analyzed by Metascape database.The results illustrated that 81 toxicological targets related to TCDD and skin aging were obtained,and the core toxicological targets were mainly MMP-1,MMP-9 and EGFR,etc.The toxicological pathway involved neuroactive ligand-receptor interaction,calcium signaling pathway and IL-17 inflammatory signaling pathway.Therefore,environmental pollutant TCDD was harmful to human skin,which may accelerate skin aging by regulating multi-target and multi-pathway.

关 键 词：2 3 7 8-四氯二苯并对二恶英(TCDD) 环境污染 皮肤老化 毒理靶点 

分 类 号：X503.1[环境科学与工程—环境工程]