碳酸锂和佐匹克隆联用致药物超敏反应综合征的病例分析及药学监护  

Case analysis and pharmaceutical monitoring of a case of drug induced hypersensitivity syndrome caused by lithium carbonate and zopiclone

作　　者：朱静[1] 陈凡[1] 张弋[1] ZHU Jing;CHEN Fan;ZHANG Yi(Department of Pharmacy,Tianjin First Central Hospital,Tianjin 300192,China)

机构地区：[1]天津市第一中心医院药学部,天津300192

出　　处：《中国处方药》2024年第8期92-94,共3页Journal of China Prescription Drug

摘　　要：目的 探讨碳酸锂和佐匹克隆联用致药物超敏反应的特点和药学监护要点。方法 临床药师参与1例服用碳酸锂和佐匹克隆后导致以肝功能损伤和皮肤重度红斑为首要临床表现的药物致超敏反应综合征患者的治疗过程,同时参考相关标准判断两种药物与超敏反应的关联性并进行相关文献分析。结果 经过早期识别并停用可疑药物后,患者经抗过敏、保肝、激素以及提高免疫力治疗后症状缓解。结论 超敏反应为碳酸锂和佐匹克隆较罕见的不良反应,用药过程中患者如出现无明显诱因的发热、皮疹时,应引起关注并及时停药,临床药师应协助医生做相关文献分析和循证支持。Objective To explore the characteristics and key points of pharmaceutical monitoring of drug hypersensitivity reaction caused by the combination of lithium carbonate and zopiclone.Methods Clinical pharmacists participated in the treatment of a patient with drug induced hypersensitivity syndrome,whose primary clinical manifestations were liver function damage and severe skin erythema,after taking lithium carbonate and zopiclone,and adjudged the relationship of two drugs with hypersensitivity reaction according to relative standards,and conduct relevant literature analysis.Results After early identification and discontinuation of the suspected sensitizing drugs and after the treatment of anti-allergy、protecting liver、hormone and improving immunity,the patient’s symptoms improved.Conclusion Hypersensitivity reaction is the rare adverse drug reaction of lithium carbonate and zopiclone,when patients experience fever or rash without obvious causes,attention should be paid and medication should be stopped in a timely manner.Clinical pharmacists should assist doctors in conducting relevant literature analysis and evidence-based support.

关 键 词：碳酸锂 佐匹克隆 药物超敏反应综合征 药学监护 

分 类 号：R969.3[医药卫生—药理学]