己酮可可碱联合炔雌醇环丙孕酮片治疗对子宫内膜异位症术后患者血液流变学的影响  

Effect of pentoxifylline combined with ethinylestradiol cyproterone tablets on hemorheology in patients with endometriosis after operation

作　　者：李欢欢 柏妍槟[1] 邓雪聪 吴梦丽 李远 李晶 李亚 LI Huan-huan;BAI Yan-bing;DENG Xue-cong(Department of Obstetrics and Gynecology,Bengbu Third People's Hospital,Bengbu 233000,China)

机构地区：[1]蚌埠市第三人民医院妇产科,安徽蚌埠233000

出　　处：《中国处方药》2024年第8期97-100,共4页Journal of China Prescription Drug

摘　　要：目的探讨己酮可可碱联合炔雌醇环丙孕酮片治疗对子宫内膜异位症(EMT)术后患者血液流变学的影响。方法选取2021年1月~2023年12月某院收治的120例EMT患者为研究对象,随机分为两组。对照组(60例)于腹腔镜保守手术后服用炔雌醇环丙孕酮片治疗,研究组(60例)在对照组基础上加用己酮可可碱治疗。对两组血液流变学指标、抗子宫内膜抗体(EMAb)、Th1/Th2漂移指标、血管内皮功能指标和不良反应进行比较分析。结果治疗后,两组血浆黏度、红细胞聚集指数、纤维蛋白原较同组治疗前下降,且研究组血浆黏度[(1.57±0.16)mPa·s]、红细胞聚集指数(3.24±0.37)、纤维蛋白原[(3.91±0.79)g/L]水平均低于对照组[(1.73±0.20)mPa·s、(3.50±0.41)、(4.37±0.87)g/L](P<0.05)。治疗后,研究组EMAb的转阴率(51.11%)高于对照组(27.91%)(P<0.05)。治疗后,两组白细胞介素-2(IL-2)和干扰素-γ(IFN-γ)水平上升,白细胞介素-4(IL-4)和白细胞介素-10(IL-10)水平下降,且研究组IFN-γ[(349.55±57.54)ng/ml]、IL-2[(5.92±1.86)ng/ml]水平高于对照组[(323.31±54.29)ng/ml、(4.97±1.77)ng/ml],IL-4[(8.30±1.43)ng/ml]、IL-10[(3.04±0.45)ng/ml]水平低于对照组[(8.99±1.36)ng/ml、(3.29±0.51)ng/ml](P<0.05)。治疗后,两组细胞间黏附分子-1(ICAM-1)和血管内皮生长因子(VEGF)水平较各组治疗前下降,且研究组ICAM-1[(295.58±53.60)ng/L]、VEGF[(68.98±10.32)ng/L]水平低于对照组[(326.29±49.73)ng/L、(74.91±11.05)ng/L](P<0.05)。治疗后,两组不良反应总发生率相比,差异无统计学意义(P>0.05)。结论己酮可可碱联合炔雌醇环丙孕酮片可以调节EMT患者的血管内皮功能指标,提高EMAb的转阴率,改善血液流变学指标,调节患者的Th1/Th2漂移指标,且安全性较高。Objective To investigate the effect of pentoxifylline combined with ethinylestradiol cyproterone tablets on the hemorheology of endometriosis(EMT)postoperative patients.Methods 120 patients with EMT admitted to a hospital from January 2021 to December 2023 were selected as the objects and randomly divided into two groups.The control group(60 cases)was treated with ethoestradiol cyproterone tablets after laparoscopic conservative surgery,and the study group(60 cases)was treated with pentoxifylline on the basis of the control group.The hemorheology indexes,anti-endometrial antibody(EMAb),Th1/Th2 drift indexes,vascular endothelial function indexes and adverse reactions were compared between the two groups.Results After treatment,the plasma viscosity,erythrocyte aggregation index and fibrinogen in the two groups were decreased when compared with those in the same group before treatment,and the levels of plasma viscosity[(1.57±0.16)mPa·s],erythrocyte aggregation index(3.24±0.37)and fibrinogen[(3.91±0.79)g/L]of the study group were lower than those of the control group[(1.73±0.20)mPa·s,(3.50±0.41),(4.37±0.87)g/L](P<0.05).After treatment,the negative conversion rate of EMAb in the study group(51.11%)was higher than that in the control group(27.91%)(P<0.05).After treatment,the levels of interleukin-2(IL-2)and interferon-γ(IFN-γ)in the two groups increased,and the levels of interleukin-4(IL-4)and interleukin-10(IL-10)decreased.The levels of IFN-γ[(349.55±57.54)ng/ml]and IL-2[(5.92±1.86)ng/ml]in the study group were higher than those in the control group[(323.31±54.29)ng/ml,(4.97±1.77)ng/ml],the levels of IL-4[(8.30±1.43)ng/ml]and IL-10[(3.04±0.45)ng/ml]were lower than those in the control group[(8.99±1.36)ng/ml,(3.29±0.51)ng/ml](P<0.05).After treatment,the levels of intercellular adhesion molecule-1(ICAM-1)and vascular endothelial growth factor(VEGF)in the two groups were lower than those before treatment,and the levels of ICAM-1[(295.58±53.60)ng/L]and VEGF[(68.98±10.32)ng/L]in the study group were lo

关 键 词：己酮可可碱 炔雌醇环丙孕酮片 EMT 血液流变学 

分 类 号：R713.4[医药卫生—妇产科学] R969.4[医药卫生—临床医学]