血清C反应蛋白和降钙素原与WBC结合谷丙转氨酶诊断小儿手足口病的临床意义  

Clinical significance of serum C-reactive protein and procalcitonin and WBC combined with alanine aminotransferase in the diagnosis of hand-foot-mouth disease in children

作　　者：李旺辉 陈方根 LI Wanghui;CHEN Fanggen(Department of Infectious Diseases,Jiangxi Children's Hospital,Nanchang,Jiangxi,330006,China)

机构地区：[1]江西省儿童医院感染科,江西南昌330006

出　　处：《当代医学》2024年第9期122-125,共4页Contemporary Medicine

摘　　要：目的分析血清C反应蛋白(CRP)、降钙素原(PCT)、WBC结合谷丙转氨酶(ALT)对小儿手足口病的影响及在患儿临床诊断中的应用价值。方法选取2019年1月至2022年1月江西省儿童医院收治的90例小儿手足口病患儿作为研究组,另选取同期于本院接受体检的90名健康儿童作为对照组。两组均检测CRP、PCT及WBC水平,研究组进行检测病毒性质检测,并检测ALT、谷草转氨酶(AST)与肌酸激酶同工酶MB(CK-MB)。比较两组血清CRP、PCT与WBC水平,根据病毒性质检测结果对研究组进行分组,比较不同病症类型患儿的WBC、ALT、AST与CK-MB水平。结果研究组CRP、PCT与WBC水平均高于对照组,差异有统计学意义(P<0.05)。4组不同病症类型患儿CK-MB水平比较差异有统计学意义(P<0.05),CA16(+)EV71(+)组、CA16(-)EV71(+)组CK-MB水平均高于CA16(+)EV71(-)组、CA16(-)EV71(-)组,差异有统计学意义(P<0.05),其余组间两两比较差异无统计学意义。结论CRP、PCT与WBC可作为小儿手足口病患儿的诊断依据,CK-MB检查可进一步确诊EV71阳性患儿。Objective To analyze the effects serum C-reactive protein(CRP),procalcitonin(PCT),WBC combined with alanine aminotransferase(ALT)on hand-foot-mouth disease in children and their application value in clinical diagnosis value.Methods 90 children with hand-foot-mouth disease admitted to Jiangxi Children's Hospital from January 2019 to January 2022 were selected as the study group,and 90 healthy children who underwent physical examination in our hospital during the same period were selected as the control group.The levels of CRP,PCT and WBC of the two groups were detected,the study group was tested for virus properties,and ALT,aspartate aminotransferase(AST) and creatine kinase MB(CK-MB)were detected.The levels of serum CRP,PCT and WBC were compared between the two groups,the study group was grouped according to the results of virus property test,and the levels of WBC,ALT,AST and CK-MB in children with different disease types were compared.Results The levels of CRP,PCT and WBC in the study group were higher than those in the control group,and the differences were statistically significant(P<0.05).The level of CK-MB in the CA16(+)and EV71(+)groups,CA16(-)and EV71(+)groups was higher than that in CA16(+)and EV71(-)groups,CA16(-)and EV71(-)groups,and the differences were statistically significant(P<0.05),there was no significant difference between the other groups.Conclusion CRP,PCT,and WBC can serve as diagnostic criteria for children with hand,foot,and mouth disease,CK-MB examination can further confirm EV71 positive children.

关 键 词：C反应蛋白 降钙元素 白细胞计数 谷丙转氨酶 小儿手足口病 

分 类 号：R725.4[医药卫生—儿科]