HLA和IL基因多态性及其与复发性自然流产的相关性  

Correlation between HLA gene and IL gene polymorphisms with recurrent spontaneous abortion

作　　者：张少华 林爱齐 张玉 董晓云 刘红英 Zhang Shaohua;Lin Aiqi;Zhang Yu;Dong Xiaoyun;Liu Hongying(Naval Medical University of PLA,Changhai Hospital,Shanghai 200433,China;CAS Key Laboratory of Experimental Marine Biology,Institute of Oceanology,Chinese Academy of Sciences,Qingdao 266071,Shandong Province,China;Department of Pediatrics,Zibo Central Hospital,Zibo 255000,Shandong Province,China;Department of Genetics,College of Biological Science and Technology,Weifang Medical College,Weifang 261053,Shandong Province,China)

机构地区：[1]中国人民解放军海军军医大学,长海医院,上海200433 [2]中国科学院海洋研究所实验海洋生物学重点实验室,青岛266071 [3]淄博市中心医院儿科,淄博255000 [4]潍坊医学院生物科学与技术学院遗传学教研室,潍坊261053

出　　处：《中华妇幼临床医学杂志（电子版）》2024年第3期251-259,共9页Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition)

基　　金：山东省科技厅自然科学基金项目(ZR2019BC095)。

摘　　要：复发性自然流产(RSA)是由多基因和多种环境因素共同作用所致的多基因遗传病,其中育龄女性遗传因素、免疫异常、内分泌功能异常、生殖系统解剖结构异常和病原微生物感染等,均可导致RSA发生。人类白细胞抗原(HLA)家族与白细胞介素(IL)家族基因多态性,在母-胎界面免疫调节中发挥重要作用。HLA和IL基因突变,可致育龄女性免疫调节功能异常,是导致育龄女性发生RSA的主要因素。笔者拟就HLA和IL基因多态性及其与RSA相关性的最新研究现状进行阐述。Recurrent spontaneous abortion(RSA)refers to a polygenic genetic disease affected by multiple pairs of genes and environmental factors,in which genetic factors,immune abnormalities,endocrine dysfunction,reproductive system anatomical structure abnormalities and microbial infections of childbearing age women can contribute to RSA.The polymorphisms of human leukocyte antigen(HLA)family genes and interleukin(IL)family genes play important roles in maternal-fetal interface immunity.Mutations of HLA and IL genes can cause abnormal immune function in women of childbearing age,as the main factors leading to RSA.This article reviews the latest research progress of correlation between HLA and IL gene polymorphisms with RSA.

关 键 词：流产 自然 流产 习惯性 复发性自然流产 基因多态性 人类白细胞抗原基因 白细胞介素基因 育龄女性 

分 类 号：R714.21[医药卫生—妇产科学]