体外受精周期中单原核胚胎的临床研究现状  

Current research status of clinical studies on monopronuclear embryos in in vitro fertilization cycles

作　　者：高青卓 康宜凡 王治鸿[2] Gao Qingzhuo;Kang Yifan;Wang Zhihong(Department of Obstetrics and Gynecology,First Hospital of Shanxi Medical University,Taiyuan 030001,Shanxi Province,China;Department of Reproductive Center,First Hospital of Shanxi Medical University,Taiyuan 030001,Shanxi Province,China)

机构地区：[1]山西医科大学第一医院妇产科,太原030001 [2]山西医科大学第一医院生殖医学中心,太原030001

出　　处：《中华妇幼临床医学杂志（电子版）》2024年第3期260-265,共6页Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition)

基　　金：山西省科技厅重点研发计划项目(201903D321163)。

摘　　要：单原核(mononuclear embryo)胚胎是指受精后16~18 h仅观察到胚胎内存在1个原核(1PN),1PN在体外受精-胚胎移植(IVF-ET)中并不罕见。由于既往发现1PN胚胎染色体异常率高,移植后,母儿临床结局不理想等原因,临床通常不采用1PN胚胎进行移植。近年随着囊胚培养和胚胎植入前遗传学检测(PGT)技术的发展,1PN胚胎越来越受到辅助生殖技术领域的关注。研究证明,部分1PN胚胎染色体正常,并且移植后,仍然可能分娩健康婴儿,故对其临床价值值得进一步探讨。笔者拟就国内外关于IVF-ET中1PN胚胎的最新研究进展现状进行阐述,重点关注1PN形成机制、1PN胚胎的染色体构成及分析,以及1PN胚胎临床结局与临床价值,旨在为IPN胚胎临床决策提供参考。Monopronuclear embryos refer to embryos in which only one pronucleus(1PN)is observed between 16 to 18 hours after fertilization,which is not uncommon in in vitro fertilization-embryo transfer(IVF-ET).Due to the high rate of chromosomal abnormalities in 1PN embryos and unsatisfactory clinical pregnancy outcomes after IVF-ET,transplantation of 1PN embryos is usually not performed.In recent years,with the development of blastocyst culture and preimplantation genetic testing(PGT)technology,1PN embryos have attracted more and more attention in the field of assisted reproductive technology experts.Studies have demonstrated that some 1PN embryos chromosomes are normal and may still deliver healthy babies after IVF-ET,so their clinical values deserve further exploration.The author intends to elaborate on the latest research progress on the mechanism of 1PN,and chromosomal composition,clinical outcome and clinical value after IVF-ET of 1PN embryos,aiming to provide ideas for the rational clinical application of 1PN embryos.

关 键 词：不育 单原核胚胎 体外受精-胚胎移植 卵裂期胚胎 胚胎植入前遗传学检测 卵胞质内单精子注射 生殖技术 辅助 

分 类 号：R714[医药卫生—妇产科学]